Cardioprotective effect of resistance training and Crataegus oxyacantha extract on ischemia reperfusion-induced oxidative stress in diabetic rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Kamal RanjbarBayan Fayazi

Abstract

Discovering an effective approach to limit infarction size after ischemia-reperfusion has a clinical importance in diabetics. We investigated the anti-myocardial ischemia-reperfusion injury effect of resistance training and Crataegus oxyacantha extract on diabetic rats. To this end, 50 male Wistar rats were randomly divided into 5 groups: the sedentary control (SC), sedentary diabetic (SD), resistance trained diabetic (RD), diabetic plus C. oxyacantha extract treatment (CD) and resistance trained diabetic plus C. oxyacantha extract treatment (RCD) groups. Animals in trained groups were subjected to progressive resistance training program with the use of a ladder (5 days/week, for 10 weeks). C. oxyacantha extract rats were treated with 100 mg/kg body weight of the extract using a gavage every day for 10 weeks. After treatments, rats were subjected to ischemia via LAD artery ligation for 30 min followed by 90 min reperfusion. The heart was collected following the ischemia-reperfusion and analyzed for oxidative stress and ischemia-reperfusion injury. Compared to the SC group, LDH, CK-MB and infarction size in the SD group were significantly higher, whereas injury indices in the RCD group were significantly lower than those in the ...Continue Reading

References

Oct 17, 1968·European Journal of Biochemistry·W G Niehaus, B Samuelsson
Jan 1, 1984·Methods in Enzymology·H Aebi
Apr 1, 1996·Journal of Applied Physiology·A N BelcastroD A Raj
Aug 26, 2000·Journal of Diabetes and Its Complications·J Y HokamaP F McDonagh
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Mar 17, 2004·The American Journal of Medicine·Richard W Nesto
Apr 23, 2005·The American Journal of Chinese Medicine·Wei-Tien ChangZuo-Hui Shao
Aug 25, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhaosheng TangLian Zhu
Jan 8, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Laura R La BontePaul F McDonagh
Jan 15, 2008·Free Radical Biology & Medicine·Scott K PowersAndreas N Kavazis
Aug 29, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Chinnasamy ElangoS Niranjali Devaraj
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Sep 18, 2010·Clinical and Experimental Immunology·M F BelottoE Hatanaka
Dec 18, 2010·Free Radical Biology & Medicine·Justin L Rains, Sushil K Jain
Jan 5, 2011·Journal of Neuroinflammation·Chinnasamy Elango, Sivasithambaram Niranjali Devaraj
Jan 15, 2011·Nature Reviews. Immunology·Marc Y Donath, Steven E Shoelson
Mar 12, 2011·Journal of Applied Physiology·Chad R FrasierDavid A Brown
Aug 16, 2011·Atherosclerosis·Allison E DeVanHirofumi Tanaka
Sep 27, 2012·The Journal of Pathology·David M Ansley, Baohua Wang
Jun 20, 2013·Cardiovascular Diabetology·Hong LiChuanshi Xiao
Apr 12, 2014·Current Cardiology Reviews·Elisabetta Marongiu, Antonio Crisafulli
Jul 16, 2016·Journal of Traditional and Complementary Medicine·Alireza KomakiNegar Baharlouei
Nov 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ebrahim ZarrinkalamAlireza Komaki

❮ Previous
Next ❯

Citations

Jul 31, 2019·International Journal of Preventive Medicine·Mahshid HosseiniMehdi Kargarfard
Mar 11, 2020·Frontiers in Pharmacology·Min WuYu Cao
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amir M Al HroobAyman M Mahmoud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.