Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats

The Journal of Pharmacy and Pharmacology
R Jayalakshmi, S Niranjali Devaraj

Abstract

Tincture of Crataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataegus oxycantha), is used in herbal and homeopathic medicine. The present study was done to investigate the protective effect of TCR on experimentally induced myocardial infarction in rats. Pretreatment of TCR, at a dose of 0.5 mL/100 g bodyweight per day, orally for 30 days, prevented the increase in lipid peroxidation and activity of marker enzymes observed in isoproterenol-induced rats (85 mg kg(-1) s. c. for 2 days at an interval of 24 h). TCR prevented the isoproterenol-induced decrease in antioxidant enzymes in the heart and increased the rate of ADP-stimulated oxygen uptake and respiratory coupling ratio. TCR protected against pathological changes induced by isoproterenol in rat heart. The results show that pretreatment with TCR may be useful in preventing the damage induced by isoproterenol in rat heart.

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Citations

Jan 1, 2013·Cardiovascular Toxicology·Gurusamy LalithaViswanadha Vijaya Padma
Apr 23, 2005·The American Journal of Chinese Medicine·Wei-Tien ChangZuo-Hui Shao
Aug 9, 2006·Journal of Ethnobiology and Ethnomedicine·Cheryl LansKarla Georges
Jan 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jie WangBo Feng
Aug 29, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Chinnasamy ElangoS Niranjali Devaraj
Jul 19, 2016·Archives of Physiology and Biochemistry·Suliman Al Humayed
Feb 22, 2012·Molecular and Cellular Biochemistry·Navin Alukkathara VijayanSivasitamparam Niranjali Devaraj
Mar 10, 2017·Journal of Toxicology and Environmental Health. Part a·Ana Paula Oliveira de QuadrosEdson Luis Maistro
Feb 23, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J K SwaminathanP Kuppusamy

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