Cardioprotective effects of an angiotensin-converting-enzyme inhibitor, imidapril, and Ca2+ channel antagonist, amlodipine, in spontaneously hypertensive rats at established stage of hypertension

Japanese Journal of Pharmacology
S YokotaH Narita

Abstract

The present study was performed to compare cardioprotective effects of an angiotensin-converting-enzyme inhibitor, imidapril, and of a Ca2+ channel antagonist, amlodipine, against the cardiac hypertrophy in male spontaneously hypertensive rats (SHRs) at the established stage of hypertension. Fifteen-week-old SHRs were given imidapril (2 and 5 mg/kg/day) or amlodipine (10 mg/kg/day) by gavage for 8 weeks. Three hours after the 1st treatment, imidapril moderately reduced blood pressure without changing heart rate, while amlodipine caused a marked reduction in blood pressure accompanied by transient tachycardia. At the end of the treatments, ventricular weight in the imidapril-treated groups was markedly lower, but that in the amlodipine-treated group was only slightly lower than that in the vehicle-treated group. Myocardial collagen content in the imidapril-treated group tended to be decreased, and significant reduction was observed in the low-dose group. In another experiment, the isolated heart of the imidapril-treated animals demonstrated better cardiac compliance than that in the vehicle-treated animals. In contrast, amlodipine failed to improve cardiac function. The present results suggest that imidapril possesses advantageo...Continue Reading

References

Jan 1, 1992·Cardiology·D R Abernethy
Jan 1, 1991·Journal of Cardiovascular Pharmacology·M A SaragoçaO L Ramos
Mar 15, 1990·Journal of the American College of Cardiology·B E Strauer
Sep 1, 1986·The American Journal of Physiology·B Rodrigues, J H McNeill
Apr 1, 1967·The American Journal of Physiology·J R NeelyH E Morgan
Jun 1, 1993·Circulation Research·W SchorbK M Baker
Jun 1, 1996·Journal of Cardiovascular Pharmacology·H NaritaY Ohmachi
Oct 1, 1996·British Journal of Pharmacology·K SchrickerA Kurtz

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Citations

May 8, 2008·Journal of Cardiovascular Pharmacology·Stephen Fernandes RodriguesZuleica B Fortes
Aug 15, 2002·Cardiovascular Drug Reviews·Kazuyoshi Hosoya, Toshihiko Ishimitsu
May 11, 2004·World Journal of Gastroenterology : WJG·Zhong-Sheng ZhuShao-Liang Chen

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