Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart

Oxidative Medicine and Cellular Longevity
Daoxu QuDong Wang

Abstract

This study aims to evaluate the cardioprotective effects of astragalin against myocardial ischemia/reperfusion (I/R) injury in isolated rat heart. The cardioprotective effects of astragalin on myocardial I/R injury were investigated on Langendorff apparatus. Adult male Sprague-Dawley rats were randomly divided into five groups. The results showed that astragalin pretreatment improved myocardial function. Compared with I/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione/glutathione disulfide (GSH/GSSG) ratio significantly increased. The levels of malondialdehyde (MDA), intracellular reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) decreased in astragalin-treated groups. The infarct size (IS) and apoptosis rate in hearts from astragalin-treated groups were lower than those in hearts from the I/R group. Western blot analysis also revealed that astragalin preconditioning significantly reduced Bax level, whereas Bcl-2 was increased in the myocardium. Therefore, astragalin exhibited cardioprotective effects via its antioxidative, antiapoptotic, and ant...Continue Reading

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Citations

Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zengyong QiaoJingyu Yang
May 23, 2017·Nutrients·Rosanna MatteraRoberto Bei
Jan 25, 2020·International Journal of Molecular Sciences·Branislav KuraMonika Bartekova
Jun 2, 2018·Advances in Pharmacological Sciences·Ammara RiazZeliha Selamoglu
Mar 29, 2019·Oxidative Medicine and Cellular Longevity·Xinyu YangHongcai Shang

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Methods Mentioned

BETA
ELISA
electrophoresis
MDA

Software Mentioned

Chart
SPSS
Image
Pro Plus

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