Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction.

Proceedings of the National Academy of Sciences of the United States of America
Rosemeire M Kanashiro-TakeuchiJoshua M Hare

Abstract

Whether the growth hormone (GH)/insulin-like growth factor 1(IGF-1) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth hormone-releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-1 independent fashion. After experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4-week period, either placebo (n = 14), rat recombinant GH (n = 8) or JI-38 (n = 8; 50 microg/kg per day), a potent GHRH agonist. JI-38 did not elevate serum levels of GH or IGF-1, but it markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, and circulating GH and IGF-1, but it did not offset the decline in cardiac structure and function. Whereas both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased antiapoptotic gene expression. The receptor for GHRH was detectable on myocytes, supporting direct activation of cardiac signal transduction. Collectively, these findings demonstrate that within the heart, GHRH agonis...Continue Reading

References

May 1, 1988·Pharmacology & Toxicology·K D JørgensenP Nilsson
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·J IzdebskiA V Schally
Mar 28, 1996·The New England Journal of Medicine·S FazioL Saccà
Jun 1, 1997·European Journal of Clinical Investigation·J IsgaardB A Bengtsson
Jul 22, 1998·Circulation Research·P Anversa, J Kajstura
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A TivestenJ Isgaard
Jun 25, 2003·Journal of the American College of Cardiology·Antonio CittadiniLuigi Saccà
Oct 14, 2003·Basic Research in Cardiology·Sabina FrascarelliRiccardo Zucchi
Feb 25, 2005·Vitamins and Hormones·Hippokratis KiarisAnastasios Kalofoutis
Aug 16, 2006·Physical Review Letters·T GorinM Znidaric
Dec 22, 2006·Genes & Development·Ichiro Shiojima, Kenneth Walsh
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Aug 12, 2009·The International Journal of Biochemistry & Cell Biology·Kristina LorenzMartin J Lohse
Jan 15, 2010·Clinical and Translational Science·Rosemeire M Kanashiro-TakeuchiJoshua M Hare

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Citations

Jun 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Federica LimanaMaurizio C Capogrossi
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nikolina DioufaHippokratis Kiaris
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rosemeire M Kanashiro-TakeuchiJoshua M Hare
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rudolf LucasAndrew V Schally
Jan 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Samirah A GomesJoshua M Hare
Aug 7, 2012·Interface Focus·F Stuart FosterS Lee Adamson
Mar 2, 2012·Neuroendocrinology·Luca SzalontayMagdolna Kovacs
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Undine SchubertBarbara Ludwig
Jan 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Miklos JaszberenyiAndrew V Schally
Jul 25, 2014·Regulatory Peptides·Ming-Jie YuanCong-Xin Huang
Feb 20, 2016·Journal of Endocrinological Investigation·R Granata
Oct 18, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xianyang ZhangAndrew V Schally
Nov 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Victoria FloreaClaudia O Rodrigues
Nov 6, 2012·Annales d'endocrinologie·Françoise Borson-ChazotUNKNOWN GTE group
May 3, 2011·Trends in Endocrinology and Metabolism : TEM·Hippokratis KiarisAndrew V Schally
Jun 8, 2011·Journal of Molecular and Cellular Cardiology·Rosemeire M Kanashiro-TakeuchiJoshua M Hare
Jun 29, 2011·Clinical and Translational Science·Rosemeire M Kanashiro-TakeuchiJoshua M Hare
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Barbara LudwigStefan R Bornstein
Aug 3, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laura KiscsatáriAnikó Görbe
Jun 20, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F Rodríguez-PachecoE García-Fuentes
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Iacopo GesmundoRiccarda Granata
Apr 2, 2015·Journal of the American Heart Association·Luiza L BagnoJoshua M Hare
Oct 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew V SchallyXianyang Zhang
Feb 13, 2014·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Jun 5, 2015·Biomedical Materials·Xuetao Sun, Sara S Nunes
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mayara C F GewehrEmer S Ferro
Oct 6, 2017·Oncotarget·Sander R DubovyAndrew V Schally
Jan 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Tania VillanovaRiccarda Granata

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