Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action

Journal of Atherosclerosis and Thrombosis
Manabu NagaoTatsuro Ishida

Abstract

High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent negative predictor of cardiovascular disease. The beneficial effect of HDL is largely attributable to its key role in reverse cholesterol transport, whereby excess cholesterol in the peripheral tissues is transported to the liver, reducing the atherosclerotic burden. However, mounting evidence indicates that HDL also has pleiotropic properties, such as anti-inflammatory, anti-oxidative, and vasodilatory properties, which may contribute in reducing the incidence of heart failure. Actually, previous data from clinical and experimental studies have suggested that HDL exerts cardioprotective effects irrespective of the presence/absence of coronary artery disease. This review summarizes the currently available evidence regarding beneficial effects of HDL on the heart beyond its anti-atherogenic property. Understanding the mechanisms of cardiac protection by HDL will provide new insight into the underlying mechanism and therapeutic strategy for heart failure.

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Citations

Oct 10, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Bo YuanYong-Jie Zhang
Jul 22, 2019·International Journal of Molecular Sciences·Kamil Jonas, Grzegorz Kopeć
Jul 15, 2020·The Journal of International Medical Research·Huiling LiuYazhou Wang
Nov 24, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ruihua LiuXiao Yang
Feb 19, 2021·Frontiers in Nutrition·Naseer AhmedFarooq Pasha
Jul 14, 2021·Diabetologia·Eva XepapadakiKyriakos E Kypreos
Nov 24, 2020·Current Vascular Pharmacology·Denise Coutinho de MirandaMauro César Isoldi

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