Cardioprotective effects of mast cell modulators in ischemia-reperfusion-induced injury in rats

Methods and Findings in Experimental and Clinical Pharmacology
A S JaggiN Singh

Abstract

This study was designed to investigate the cardioprotective effects of pharmacological interventions, modulating resident cardiac mast cells, on ischemia-reperfusion-induced injury. Isolated rat hearts were mounted on Langendorff apparatus and subjected to 30-min global ischemia followed by 120-min reperfusion. The extent of mast cell degranulation was assessed by release of mast cell peroxidase (MPO). The release of lactate dehydrogenase (LDH) and creatine kinase (CK) and estimation of infarct size were used to assess the extent of myocardial injury. Left ventricle developed pressure (LVDP) and its derivatives, that is, dp/dt(max) and dp/dt(min), were recorded to evaluate the postischemic recovery of the contractility of heart. Ketotifen (0.1 microM) and low-dose carvedilol (0.1 microM), without beta-blockade activity, attenuated ischemia-reperfusion-induced mast cell degranulation along with the reduction in myocardial injury, suggesting the protective effects of mast cell stabilization during ischemia and reperfusion. Administration of compound 48/80 (1 microg/ml), a specific mast cell degranulating agent, completely degranulated cardiac mast cells before global ischemia. Moreover, it also resulted in the attenuation of isch...Continue Reading

Citations

Aug 12, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mu-qing YangJi-yu Li
Sep 2, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Tyler H RorkJoel Linden
May 9, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Preet AnandNirmal Singh
Mar 4, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Gitika KhannaAmteshwar S Jaggi
May 5, 2009·Ocular Immunology and Inflammation·Manabu Mochizuki, Arun D Singh
Nov 5, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Roohani SharmaAmteshwar Singh Jaggi
Jan 18, 2012·Journal of Cellular and Molecular Medicine·Massimo CollinoEmanuela Masini
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Aug 26, 2010·Cardiovascular Research·Scott P LevickJoseph S Janicki
Jan 24, 2016·Biochimica Et Biophysica Acta·Susanne Sattler, Nadia Rosenthal
Apr 1, 2018·Cardiovascular Therapeutics·Lovedeep SinghAmteshwar S Jaggi
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Mar 3, 2019·Cardiovascular Research·Ioanna AndreadouDerek J Hausenloy
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Kamaldeep KaurAmteshwar Singh Jaggi
Mar 19, 2016·British Journal of Pharmacology·Fabio Di LisaRainer Schulz
Jul 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei XiongJinqiao Qian

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