Cardioprotective role of endogenous hydrogen peroxide during ischemia-reperfusion injury in canine coronary microcirculation in vivo

American Journal of Physiology. Heart and Circulatory Physiology
T YadaF Kajiya

Abstract

We have recently demonstrated that endogenous H2O2 plays an important role in coronary autoregulation in vivo. However, the role of H2O2 during coronary ischemia-reperfusion (I/R) injury remains to be examined. In this study, we examined whether endogenous H2O2 also plays a protective role in coronary I/R injury in dogs in vivo. Canine subepicardial small coronary arteries (>or=100 microm) and arterioles (<100 microm) were continuously observed by an intravital microscope during coronary I/R (90/60 min) under cyclooxygenase blockade (n=50). Coronary vascular responses to endothelium-dependent vasodilators (ACh) were examined before and after I/R under the following seven conditions: control, nitric oxide (NO) synthase (NOS) inhibitor NG-monomethyl-L-arginine (L-NMMA), catalase (a decomposer of H2O2), 8-sulfophenyltheophylline (8-SPT, an adenosine receptor blocker), L-NMMA+catalase, L-NMMA+tetraethylammonium (TEA, an inhibitor of large-conductance Ca2+-sensitive potassium channels), and L-NMMA+catalase+8-SPT. Coronary I/R significantly impaired the coronary vasodilatation to ACh in both sized arteries (both P<0.01); L-NMMA reduced the small arterial vasodilatation (both P<0.01), whereas it increased (P<0.05) the ACh-induced coro...Continue Reading

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Citations

Feb 9, 2010·Pflügers Archiv : European journal of physiology·Hiroaki Shimokawa
Mar 19, 2008·Medical & Biological Engineering & Computing·Masami Goto, Seiichi Mochizuki
Aug 13, 2008·The Journal of Experimental Medicine·Aya TakakiHiroaki Shimokawa
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Feb 28, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Shuichi Hamasaki, Chuwa Tei
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Mar 10, 2009·Free Radical Biology & Medicine·Sonia EliginiSusanna Colli
Feb 4, 2009·British Journal of Pharmacology·Michel Félétou
Oct 1, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Judy M Muller-DelpChristiaan Leeuwenburgh
Mar 29, 2014·Oxidative Medicine and Cellular Longevity·Paulo C SchenkelAdriane Belló-Klein
Sep 25, 2007·Journal of the American College of Cardiology·Toyotaka YadaFumihiko Kajiya
Oct 17, 2008·Journal of cardiology·Hiroaki Shimokawa, Satoshi Yasuda
Dec 19, 2016·Free Radical Biology & Medicine·Shigeo Godo, Hiroaki Shimokawa
Aug 2, 2017·Antioxidants & Redox Signaling·Amanda J LeBlanc, Natia Q Kelm
May 3, 2012·Circulation Research·Sota NakajimaHiroaki Shimokawa
Sep 28, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Toyotaka YadaFumihiko Kajiya
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Nov 27, 2008·Journal of Cardiovascular Pharmacology·Aya TakakiHiroaki Shimokawa
Dec 18, 2019·Basic & Clinical Pharmacology & Toxicology·Hiroaki Shimokawa, Shigeo Godo
Nov 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Toyotaka YadaFumihiko Kajiya
May 13, 2014·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Toyotaka Yada
Nov 30, 2021·Journal of Cardiovascular Pharmacology·Shigeo GodoHiroaki Shimokawa

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