Cardioprotective role of IGF-1 in the hypertrophied myocardium of the spontaneously hypertensive rats: A key effect on NHE-1 activity

Acta Physiologica
Alejandra M YevesIrene L Ennis

Abstract

Myocardial Na+ /H+ exchanger-1 (NHE-1) hyperactivity and oxidative stress are interrelated phenomena playing pivotal roles in the development of pathological cardiac hypertrophy and heart failure. Exercise training is effective to convert pathological into physiological hypertrophy in the spontaneously hypertensive rats (SHR), and IGF-1-key humoral mediator of exercise training-inhibits myocardial NHE-1, at least in normotensive rats. Therefore, we hypothesize that IGF-1 by hampering NHE-1 hyperactivity and oxidative stress should exert a cardioprotective effect in the SHR. NHE-1 activity [proton efflux ( J H + ) mmol L-1  min-1 ], expression and phosphorylation; H2 O2 production; superoxide dismutase (SOD) activity; contractility and calcium transients were measured in SHR hearts in the presence/absence of IGF-1. IGF-1 significantly decreased NHE-1 activity ( J H + at pHi 6.95: 1.39 ± 0.32, n = 9 vs C 3.27 ± 0.3, n = 20, P < .05); effect prevented by AG1024, an antagonist of IGF-1 receptor (2.7 ± 0.4, n = 7); by the PI3K inhibitor wortmannin (3.14 ± 0.41, n = 7); and the AKT inhibitor MK2206 (3.37 ± 0.43, n = 14). Moreover, IGF-1 exerted an antioxidant effect revealed by a significant reduction in H2 O2 produ...Continue Reading

References

Nov 1, 1994·Metabolism: Clinical and Experimental·E T PoehlmanK C Copeland
Aug 1, 1995·Journal of Molecular and Cellular Cardiology·A E Schussheim, G K Radda
Sep 24, 1998·The Journal of Clinical Endocrinology and Metabolism·M Y DonathW Kiowski
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jan 29, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M ScheinowitzM Eldar
May 7, 2003·Hypertension·Irene L EnnisHoracio E Cingolani
Sep 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Julie R McMullenSeigo Izumo
Nov 24, 2004·Biochemical and Biophysical Research Communications·Feng-Feng ZhouXuebiao Yao
Feb 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Irene L EnnisHoracio E Cingolani
Apr 26, 2006·Circulation·Brian DeBoschAnthony J Muslin
Jul 25, 2006·Journal of Molecular and Cellular Cardiology·Raúl A DulceMaría C Camilión de Hurtado
Dec 28, 2006·Hypertension·Eiki Takimoto, David A Kass
Mar 7, 2007·Circulation·Horacio E Cingolani, Irene L Ennis
May 6, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Song-Jung KimGeorge J Crystal
Jul 30, 2008·Cell·Wang WangHeping Cheng
Sep 2, 2008·Circulation Research·Andrew K SnabaitisMetin Avkiran
Sep 20, 2008·Journal of Applied Physiology·Carolina D GarciarenaIrene L Ennis
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·María Cecilia AlvarezSusana M Mosca
Jan 31, 2009·Journal of Applied Physiology·Carolina D GarciarenaIrene L Ennis
Sep 12, 2009·Journal of Molecular and Cellular Cardiology·Hiroyuki IkedaIssei Komuro
Feb 9, 2011·Pflügers Archiv : European journal of physiology·Horacio E CingolaniNéstor G Pérez
Feb 23, 2013·Journal of Molecular and Cellular Cardiology·Shigeo WakabayashiTomoe Y Nakamura
Aug 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Juliane C CamposJulio C B Ferreira
Jan 2, 2014·Trends in Endocrinology and Metabolism : TEM·Rodrigo TroncosoSergio Lavandero
Sep 23, 2014·Journal of Molecular and Cellular Cardiology·Alejandra M YevesIrene L Ennis
Nov 22, 2014·PloS One·Juliana P BorgesMarcos Adriano Lessa
Mar 10, 2015·Journal of Applied Physiology·Mariela B NollyPatricio E Morgan
Sep 5, 2017·Journal of Molecular and Cellular Cardiology·Juan I BurgosIrene L Ennis

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Citations

Mar 15, 2019·Acta Physiologica·Susanne Ackermann, Ralf Mrowka
May 9, 2019·Acta Physiologica·Ralf Mrowka
Jul 23, 2019·Acta Physiologica·Mathias SteinachMichael Fähling

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