Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat

Life Sciences
J M DielemanC J Kalkman

Abstract

Neurologic and neurocognitive complications after cardiac surgery with cardiopulmonary bypass (CPB) have been reported repeatedly. To better understand its etiology and design protective strategies, an appropriate animal model may prove useful. Although impaired short-term neurocognitive function has been recently demonstrated after CPB in rats, the demonstration of persistent long-term neurocognitive changes would be more relevant from a clinical perspective. We hypothesized that CPB results in long-term impairment of neurocognitive performance in rats. Male rats were exposed to either 60 min of normothermic non-pulsatile CPB, using a roller-pump and a neonatal membrane oxygenator, or to cannulation only (sham animals). Long-term neurocognitive function was assessed at 4 to 7 weeks after CPB (Can test), and again after 12 weeks (Morris water maze) in both operated groups and in a non-operated control group, followed by histologic evaluation of the hippocampus. In separate groups of CPB and sham animals, we also measured TNF-alpha and IL-6 in plasma. There were no significant differences in long-term neurocognitive performance or histological outcome between the three groups. Cytokine patterns were also similar in both operated...Continue Reading

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Citations

Aug 21, 2008·Journal of Cardiothoracic Surgery·Fellery de LangeG Burkhard Mackensen
Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tao XuXiao-ming Deng
May 16, 2009·Journal of Anesthesia·Anne-Mette SauërDiederik van Dijk
Oct 17, 2009·Journal of Cardiothoracic and Vascular Anesthesia·H Mayumi HomiHilary P Grocott
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Bettina JungwirthEberhard F Kochs
Feb 24, 2015·Mediators of Inflammation·Shuhua LuoQi An
May 19, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Bettina Jungwirth, Fellery de Lange

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