PMID: 9160361Mar 1, 1997Paper

Cardiopulmonary bypass (CPB) for lung transplantation

Perfusion
C C HlozekM Perl

Abstract

Surgeons have often been reluctant to use cardiopulmonary bypass (CPB) during single (SLTx) and double lung (DLTx) transplantation surgery because of the potential adverse sequelae of CPB including haemorrhage and activation of complement leading to sequestration of neutrophils and platelets in the pulmonary capillary bed, endothelial damage, increased capillary permeability and pulmonary oedema. To clarify the effect of CPB on lung transplant recipients, we reviewed our last four years' experience in 74 patients of whom 30 required CPB support. Indications for CPB were mean pulmonary artery pressure of greater than 50 mmHg, haemodynamic instability, hypoxia or hypercarbia. Patients undergoing SLTx were placed on CPB via the femoral artery and vein, while those undergoing DLTx were cannulated in the standard fashion using the ascending aorta and right atrium. All patients were administered aprotinin prior to CPB. Intraoperatively and postoperatively, haemorrhage was not a major problem. The 30-day mortality in the CPB group and the non-CPB group were 20% and 4.6%, respectively which was not statistically significant (p = 0.06). We conclude that CPB during lung transplantation is a safe, effective method to support these severel...Continue Reading

References

Apr 1, 1995·The Annals of Thoracic Surgery·S KestenJ R Maurer
Mar 1, 1994·The Annals of Thoracic Surgery·R AebaR L Hardesty
May 1, 1994·The Annals of Thoracic Surgery·A N TriantafillouD G Lappas

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Citations

Jun 21, 2012·Interactive Cardiovascular and Thoracic Surgery·Clare BurdettStephen C Clark
Jun 11, 2010·Transplantation Proceedings·D DisoG F Coloni
Oct 7, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Nicolas DalibonMarc Fischler
May 31, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Kathirvel Subramaniam, Jean-Pierre Yared
May 23, 2002·Perfusion·K S NairK M Taylor
Oct 23, 2020·Expert Review of Medical Devices·Noah WeingartenHaytham Elgharably

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