PMID: 16322732Dec 3, 2005Paper

Cardiopulmonary bypass in ewe's fetus: advances and setbacks in our learning curve

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
A CruceanF Coceani

Abstract

Fetal cardiac surgery represents a surgical challenge and several centers are attempting to establish a suitable methodology in animals. We present our experience with extra-corporeal bypass procedures in preterm and term sheep fetuses. Twenty-two fetuses (103-139 days gestation, mean 115 days gestation) underwent a 1-hour period of right heart-to-pulmonary artery extracorporeal circulation followed by 1 hour of observation. Animals were divided into group 1 and group 2, according to gestational age (above and below 0.85). Three pumps were used: centrifugal without (group 1) reservoir, centrifugal with (group 2) reservoir, and roller with reservoir (group 2). Experiments were completed in 75% of fetuses in group 1 and in 37% of fetuses in group 2. Bleeding was the main cause of failure, especially for group 2. A slow deterioration of blood gas status was noted in group 1, while this trend could be partially reversed in group 2 with corrective measures. Complete heart bypass could not be achieved in either group, and residual fluctuations in arterial pressure were observed. During bypass, body temperature decreased more in group 2 than in group 1. We conclude that cardiac bypass is feasible over a short period in near-term fetus...Continue Reading

References

Oct 1, 1975·Journal of Animal Science·L J KoongP V Rattray
Aug 21, 2001·Pediatric Annals·R S Wagner
Feb 15, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A PeroloG Pilu
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Dec 23, 2004·Prenatal Diagnosis·Torvid Kiserud, Ganesh Acharya

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Citations

Mar 22, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Akif Undar
Apr 7, 2010·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Flavio CoceaniBruno Murzi
Jan 27, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Akif Undar
Jun 7, 2012·The International Journal of Artificial Organs·Costantino Del GaudioUmberto Morbiducci

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