Abstract
Patients with chronic heart failure (CHF) are characterized by abnormal gas exchange and ventilatory responses to exercise. This study compares variables obtained from cardiopulmonary exercise testing in 35 patients with CHF with 35 age- and weight-matched healthy subjects. A second goal was to obtain cardiopulmonary variables measured at ventilatory threshold to distinguish patient changes from those of healthy subjects. Exercise testing was carried out using bicycle ergometry with ramplike protocol (work rate increments 12.5 W/min). Gas exchange and ventilation were measured breath by breath. Compared with healthy subjects, the VO2 in patients was lower at identical work rates (p < 0.004) and at ventilatory threshold (p < 0.0001), and the slope of the VO2 curve during incremental exercise was flatter (p < 0.05). With the exception of heart rate, the variables for VO2, VCO2, ventilation, O2 pulse, ventilatory equivalents for O2 and CO2, and VD/VT (physiologic deadspace to tidal volume ratio), as well as lactate differed significantly at identical work rates. With the exception of VD/VT, all cardiopulmonary variables showed significant differences in their slopes during exercise. By means of a discriminant analysis, VCO2 and ve...Continue Reading
References
Sep 1, 1976·Progress in Cardiovascular Diseases·R Ingram, E R McFadden
Sep 1, 1992·American Heart Journal·J MyersV F Froelicher
May 1, 1992·Japanese Circulation Journal·H ItohK Taniguchi
Jul 1, 1992·Journal of the American College of Cardiology·A KoikeF Marumo
Oct 1, 1991·Circulation·M J SullivanF R Cobb
Jul 1, 1990·Journal of the American College of Cardiology·A C SolalR Gourgon
Dec 1, 1988·The American Journal of Cardiology·D M ManciniJ R Wilson
Mar 1, 1988·Circulation·M J SullivanF R Cobb
Aug 1, 1987·The American Journal of Cardiology·B M MassieB Rajagopalan
Mar 1, 1987·The American Journal of Cardiology·J E HansenK Wasserman
Feb 1, 1986·The American Journal of Cardiology·L I FinkN Ferraro
Aug 1, 1983·Circulation·N MatsumuraH Yasuda
Dec 1, 1984·American Heart Journal·J M RobertsJ Myers
Feb 1, 1993·Circulation·J R WilsonW B Dunkman
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·K MeyerH Roskamm