Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan

Shock
M WanecekE Weitzberg

Abstract

In a porcine endotoxin shock model, the mixed nonpeptide endothelin receptor antagonist bosentan was administered 2 h after onset of endotoxemia (n = 8). Cardiopulmonary vascular changes, oxygen-related variables, and plasma levels of endothelin-1-like immunoreactivity were compared with a control group that received only endotoxin (n = 8). Bosentan abolished the progressive increase in mean pulmonary artery pressure and pulmonary vascular resistance seen in controls. Possible mechanisms include blockade of vasoconstrictive endothelin receptors, and a lesser degree of edema and inflammation indicated by less alveolar protein and a lower inflammatory cell count observed in bronchoalveolar lavage. Further, bosentan restored cardiac index to the pre-endotoxin level by an increase in stroke volume index, improved systemic oxygen delivery, and acid base balance. Because mean arterial blood pressure was unaffected, bosentan reduced systemic vascular resistance. Endotoxemia resulted in an increase in tumor necrosis factor-alpha and endothelin-1-like immunoreactivity plasma levels, the latter being further increased by bosentan. In conclusion, in porcine endotoxemia, treatment with the endothelin receptor antagonist bosentan, administe...Continue Reading

Citations

Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Aug 12, 2003·European Journal of Pharmacology·Mariangela AlbertiniSabah N A Hussain
May 13, 1999·Critical Care Medicine·A OldnerA Sollevi
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Vladimir KuklinLars Bjertnaes
Jun 27, 2002·Expert Opinion on Investigational Drugs·Lewis J Rubin, Sébastien Roux
Apr 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Joel S HolgerJohn J Marini
Aug 17, 2010·British Journal of Anaesthesia·A AnderssonR Frithiof
Aug 26, 2009·Journal of Intensive Care Medicine·Martin W Dünser, Walter R Hasibeder
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·A SomellH Hjelmqvist
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·D KonradA Oldner
Sep 27, 2003·Acta Physiologica Scandinavica·R J M Middelveld, K Alving
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Wendy JohnsonMark A Creager
Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C M PastorA K Nussler
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Mladen KnotekRobert W Schrier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.