PMID: 9430771Feb 7, 1998Paper

Cardiopulmonary effects of clonidine, diazepam and the peripheral alpha 2 adrenoceptor agonist ST-91 in conscious sheep

Journal of Veterinary Pharmacology and Therapeutics
C S CellyS S Young

Abstract

The cardiopulmonary effects of the intravenous administration of clonidine (15 micrograms/kg), ST-91 (30 micrograms/kg) and diazepam (0.4 mg/kg) were compared in five healthy sheep using a randomized cross-over design, to determine whether the hypoxaemic effects of alpha 2 adrenoceptor agonists are due to sedation, or to peripheral alpha 2 adrenoceptor stimulation. All three drugs significantly lowered arterial oxygen tension (PaO2) levels within 2 min of their administration; however, clonidine and ST-91 produced long lasting and severe hypoxaemia with mean PaO2 levels of approximately equal to 40 mm Hg and 50 mm Hg (5.3 kPa and 6.6 kPa), respectively. The fall in PaO2 was considerably less with diazepam (63 mm Hg or 8.4 kPa at 2 min) and by 15 min the values did not differ from placebo treated animals. None of the drugs increased arterial carbon dioxide tension (PaCO2) levels when compared to saline treatment and the acid base variables did not show any significant change. A significant increase was recorded in the packed cell volume of the ST-91 treated group throughout the study. Within 2 min of their administration, all drugs caused a significant increase in mean arterial pressure (MAP) as compared to the placebo treated g...Continue Reading

Citations

Jan 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·B RanheimT E Horsberg
Jun 21, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S B KästnerR Bettschart-Wolfensberger
Nov 3, 2005·American Journal of Veterinary Research·Sabine B R KästnerMirja K Huhtinen
Jan 17, 2007·Research in Veterinary Science·S B R KästnerM K Huhtinen
Sep 2, 2005·Veterinary Anaesthesia and Analgesia·M Christina Haerdi-LandererGina Neiger-Aeschbacher
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·S B R KästnerM Huhtinen
Jan 18, 2006·Veterinary Anaesthesia and Analgesia·Sabine B R KästnerRegula Bettschart-Wolfensberger
Feb 16, 2006·Veterinary Anaesthesia and Analgesia·Sabine B R Kästner
Sep 4, 2021·Journal of Veterinary Pharmacology and Therapeutics·Magdy AdamKati Salla

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