Cardiopulmonary effects of HI-6 treatment in soman intoxication

Journal of Applied Toxicology : JAT
A Göransson-Nyberg, G Cassel

Abstract

The cardiopulmonary effects of HI-6, together with atropine and soman, were studied in the rat. HI-6 is an effective antidote in acute poisoning with the nerve agent soman. The therapeutic efficiency of HI-6 is still unclear and cannot be explained entirely by the HI-6 reactivating ability of acetylcholinesterase (AChE). Other non-cholinergic factors must be involved. One possible detoxifying process might be an effect of HI-6 on the blood flow to sensitive organs. The purpose of the present study was to investigate 1) whether soman per se induces changes in regional blood flow and 2) whether the blood flow to different organs is affected when HI-6 (50 mg x kg(-1) i.m.) and atropine (10 mg x kg(-1) i.m.) are given either before or immediately after soman intoxication (90 microg x kg(-1) s.c.). For regional blood flow determinations the microsphere method was used with male Wistar rats weighing 300-400 g. The rats were anaesthetised and breathed spontaneously during the experiment. Three different blood flow measurements were made in the same animal and concomitant physiological parameters such as mean arterial blood pressure and respiratory rate were recorded. The blood AChE activity was followed throughout the experiment. Our ...Continue Reading

References

Apr 1, 1971·The American Journal of Medicine·T NambaD Grob
Mar 1, 1981·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·O L WolthuisE Meeter
Nov 1, 1983·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J G Clement
Apr 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B BoskovićD Jovanović
Jan 1, 1995·Archives of Toxicology·A Göransson-NybergS A Persson
Jul 30, 1997·European Journal of Pharmacology·G CasselA Göransson-Nyberg

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Citations

Jul 18, 2001·Neurotoxicology·I SvenssonG Cassel

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