Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies

Veterinary Anaesthesia and Analgesia
Miguel Gozalo MarcillaFrank Gasthuys

Abstract

To evaluate the cardiopulmonary effects of two different constant rate infusions (CRI) of dexmedetomidine (1 and 1.75 microg kg(-1 )hour(-1)) in experimental ponies. Six healthy ponies (mean 306 +/- SD 71 kg, 7.0 +/- 1.6 years). Prospective, randomized, experimental study. After premedication with intravenous (IV) dexmedetomidine (3.5 microg kg(-1)), anaesthesia was induced (T0) with ketamine (2.2 mg kg(-1) IV) and midazolam (0.06 mg kg(-1) IV) and maintained with isoflurane (Fe'ISO 1.50%) in 55% oxygen for 150 minutes. Normocapnia was maintained using artificial ventilation. Three ponies received dexmedetomidine CRIs of 1 and 1.75 microg kg(-1 )hour(-1) from T30 to T60 and T90 to T120 respectively. In the other three ponies, the order of the doses was reversed. Continuous monitoring included pulse oximetry, electrocardiography, anaesthetic gas monitoring, arterial and central venous pressures. Cardiac output (LiDCO technique) was measured and arterial and venous bloods taken every 15 minutes. Cardiac index (CI), systemic vascular resistance (SVR), arterial and venous oxygen content (CaO(2), CvO(2)) and oxygen delivery (DO(2)) were calculated. Analysis of variance with separate models for each CRI rate was used to detect differ...Continue Reading

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Citations

Apr 29, 2014·Research in Veterinary Science·S Quirós CarmonaR J Gómez-Villamandos
Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Alexander Valverde
May 30, 2013·Veterinary Anaesthesia and Analgesia·Perrine Benmansour, Tanya Duke-Novakovski
Mar 29, 2014·Veterinary Anaesthesia and Analgesia·Perrine BenmansourTanya Duke-Novakovski
Jul 6, 2014·Veterinary Anaesthesia and Analgesia·Tanya Duke-NovakovskiAndres F Sanchez-Teran
Sep 18, 2014·Journal of Veterinary Pharmacology and Therapeutics·B RanheimH A Haga
Aug 22, 2017·The Veterinary Record·Luíza Quintão MedeirosAntonio José de Araujo Aguiar
Mar 14, 2020·Journal of Veterinary Pharmacology and Therapeutics·Alonso GuedesSandra Allweiler
Dec 12, 2017·Journal of Veterinary Pharmacology and Therapeutics·M Gozalo-MarcillaS Schauvliege

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