Cardiopulmonary malformations in the inv/inv mouse

The Anatomical Record
T C McQuinnA Wessels

Abstract

The inv/inv mouse carries an insertional mutation in the inversin gene, (inv, for inversion of embryonic turning). Previously it had been reported that almost 100% of the homozygous offspring (inv/inv) were characterized by situs inversus totalis. In this report we identify the spectrum of cardiopulmonary anatomical abnormalities in inv/inv mice surviving to birth to determine whether the abnormalities seen are of the categories classically associated with human situs abnormalities. Stillborn mice, offspring that died unexpectedly (within 48 hr after birth), and neonates with phenotypic characteristics of situs inversus (right-sided stomachs, growth failure or jaundice) were processed for standard histological examination. Of 173 offspring, 34 (20%) neonates (11 stillborn, 9 unexpected deaths, and 14 mice with situs inversus phenotype) were examined, 27 of which were genotyped to be inv/inv. Interestingly, three inv/inv mice (11%) were found to have situs solitus. Twenty-four had situs inversus with normal, mirror-image cardiac anatomy (dextrocardia with atrioventricular concordance, ventriculoarterial concordance and a right aortic arch). The overall incidence of cardiovascular anomalies observed was 10 out of 27 (37%). The mo...Continue Reading

References

Jul 1, 1976·The Journal of Pediatrics·H P GutgesellD G McNamara
Apr 30, 1993·Science·T YokoyamaP A Overbeek
Nov 14, 1997·Nature Genetics·M GebbiaB Casey
Feb 19, 1998·Developmental Biology·P G MelloyC W Lo
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·J R MarszalekL S Goldstein
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M V MazziottiD H Perlmutter
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·T TsukuiJ C Belmonte
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·J HeyerR Kucherlapati
Mar 15, 2000·Developmental Biology·H ChangM M Matzuk
May 3, 2000·Methods in Molecular Biology·B R Waller, A Wessels
Apr 1, 1964·The American Journal of Cardiology·R VANPRAAGHJ D KEITH
Jul 24, 2007·Indian Journal of Dermatology, Venereology and Leprology·S Amladi

❮ Previous
Next ❯

Citations

Aug 28, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Salvatore BellaviaYves Pirson
Nov 27, 2007·The Journal of Clinical Investigation·Serena Y TanCecilia W Lo
May 9, 2012·Disease Models & Mechanisms·Dominic P Norris, Daniel T Grimes
Jan 1, 2013·Journal of the American Society of Nephrology : JASN·Danielle K ManningDavid R Beier
Feb 16, 2008·Journal of the American Veterinary Medical Association·April M Durant
Jan 30, 2009·Kidney International·Kálmán ToryRémi Salomon
Jan 21, 2015·Nature Communications·Peter G CzarneckiJagesh V Shah
May 21, 2004·Clinical Genetics·K Maclean, S L Dunwoodie
May 4, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deborah J Henderson, Bill Chaudhry
May 21, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sherry Aw, Michael Levin
Jul 29, 2008·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Jörg Männer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.