PMID: 375941May 1, 1979Paper

Cardiopulmonary manifestations of progressive systemic sclerosis: associations with circulating immune complexes and fluorescent antinuclear antibodies

Arthritis and Rheumatism
E PiskoH Rothberger

Abstract

Sixteen patients with progressive systemic sclerosis were evaluated for cardiopulmonary manifestations of their disease and for serologic immune abnormalities. Twenty-five percent of patients had abnormal echocardiograms, and 81% had a significant reduction in pulmonary function by spirometry. Circulating immune complexes (IC) were detected in 44% of patients by using a fluorescent Raji cell assay, and these patients were more likely to have an abnormal echocardiogram (P less than 0.02). Seventy-five percent of the patients had fluorescent antinuclear antibodies (FANA) and these patients were more likely to have pulmonary disease (P less than 0.01).

References

Jan 1, 1976·The Journal of Clinical Investigation·A N TheofilopoulosF J Dixon
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Nov 1, 1977·Annals of Internal Medicine·J F CipolettiG P Rodnan
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Citations

Jan 1, 1981·Springer Seminars in Immunopathology·T J Lawley, R P Hall
Feb 1, 1985·Annals of the Rheumatic Diseases·M A FrenchN R Rowell
Sep 1, 1982·The American Journal of Medicine·P D SchneiderF M Wigley
Dec 1, 1984·The American Journal of Medicine·M Peters-GoldenF M Wigley
Jan 1, 1984·Immunological Communications·Z SwierczynskaS Luft
Oct 1, 1982·Arthritis and Rheumatism·J R SeiboldG P Rodnan
Feb 1, 1991·Annals of the Rheumatic Diseases·A J Silman
Oct 1, 1982·Arthritis and Rheumatism·K SiminovitchE Keystone
Mar 1, 1980·Arthritis and Rheumatism·W J Koopman, R E Schrohenloher
Sep 1, 1981·Arthritis and Rheumatism·P C DauR W Sagebiel
Jan 1, 1987·Chest·G R Owens, W P Follansbee
Sep 1, 1984·Journal of the American Academy of Dermatology·Z Y ChenR L Dobson

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