Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial.

The European Respiratory Journal
T. SonnweberIvan Tancevski

Abstract

After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking. In this prospective, multicentre, observational study, we systematically evaluated the cardiopulmonary damage in subjects recovering from COVID-19 at 60 and 100 days after confirmed diagnosis. We conducted a detailed questionnaire, clinical examination, laboratory testing, lung function analysis, echocardiography and thoracic low-dose computed tomography (CT). Data from 145 COVID-19 patients were evaluated, and 41% of all subjects exhibited persistent symptoms 100 days after COVID-19 onset, with dyspnoea being most frequent (36%). Accordingly, patients still displayed an impaired lung function, with a reduced diffusing capacity in 21% of the cohort being the most prominent finding. Cardiac impairment, including a reduced left ventricular function or signs of pulmonary hypertension, was only present in a minority of subjects. CT scans unveiled persisting lung pathologies in 63% of patients, mainly consisting of bilateral ground-glass opacities and/or r...Continue Reading

References

Feb 21, 2003·The New England Journal of Medicine·Margaret S HerridgeUNKNOWN Canadian Critical Care Trials Group
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Jun 10, 2006·American Journal of Respiratory and Critical Care Medicine·Angela M CheungMargaret S Herridge
Jan 16, 2008·Radiology·David M HansellJacques Remy
May 2, 2008·Experimental Physiology·Yumiko ImaiJosef M Penninger
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jenny C NgaiDavid S Hui
Mar 23, 2013·The European Respiratory Journal·Ellen L BurnhamGregory P Downey
Nov 2, 2017·The Indian Journal of Radiology & Imaging·Karuna M DasRuth D Langer
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 19, 2020·Science·John B Moore, Carl H June
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
May 10, 2020·The European Respiratory Journal·Xiaoneng MoShiyue Li
May 18, 2020·Cell·Daniel Blanco-MeloBenjamin R tenOever
Jun 20, 2020·The European Respiratory Journal·Justine Frija-MassonCatherine Bancal
Jul 11, 2020·Critical Care : the Official Journal of the Critical Care Forum·Sebastian J KleinMichael Joannidis
Sep 4, 2020·BMC Medicine·Eleanor M ReesGwenan M Knight

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Citations

Feb 25, 2021·Physiological Reports·Giovanni Barisione, Vito Brusasco
Apr 6, 2021·Current Opinion in Physiology·Max ThomasJames H Hull
Apr 28, 2021·Expert Review of Respiratory Medicine·Suzana Erico TanniBruno Guedes Baldi
Jan 1, 2021·The European Respiratory Journal·Joan B SorianoJordi Rello
May 1, 2021·The European Respiratory Journal·Rocco Francesco RinaldoStefano Centanni
Feb 19, 2021·European Journal of Physical and Rehabilitation Medicine·Alessandro de SireUNKNOWN International Multiprofessional Steering Committee of Cochrane Rehabilitation REH-COVER Action
May 13, 2021·High Altitude Medicine & Biology·Andrew M Luks, Colin K Grissom
May 25, 2021·Frontiers in Medicine·Mirjam KienerMarianna Kruithof-de Julio
Jul 7, 2021·Frontiers in Endocrinology·Lukas LanserRosa Bellmann-Weiler
Jul 14, 2021·Deutsche medizinische Wochenschrift·Fabian LeoChristian Grohé
Jul 14, 2021·Expert Review of Respiratory Medicine·Angelica TiotiuGuillermo Guidos
Jun 26, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Mohammad Said RamadanUNKNOWN Monaldi Hospital Cardiovascular Infection Study Group
Jul 22, 2021·Journal of Medical Virology·Tarun K SuvvariVenkataramana Kandi
Jul 31, 2021·Cardiovascular Drugs and Therapy·Michele CorrealeNatale Daniele Brunetti
Jun 3, 2021·The Journal of Trauma and Acute Care Surgery·Elinore J KaufmanNiels D Martin
Aug 28, 2021·Respiratory Research·Anna LindahlMika Juhani Mäkelä
Aug 28, 2021·Biomedicines·Diana C Sanchez-RamirezRodrigo Torres-Castro
Jun 16, 2021·Current Opinion in Pulmonary Medicine·Thomas M CascinoYogendra Kanthi
Sep 3, 2021·Pneumologie·Andreas Rembert KoczullaRalf Harun Zwick
Sep 10, 2021·Reviews in Medical Virology·Mohammad ZareiMehdi Ghasemi
Mar 9, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Verena RassRaimund Helbok
Sep 29, 2021·BMJ Global Health·Melina MichelenCharitini Stavropoulou
Oct 24, 2021·American Journal of Hematology·Eleni KorompokiEvangelos Terpos
Nov 26, 2021·Aerospace Medicine and Human Performance·Samuel Ying KoErnest Castro Lee
Nov 27, 2021·Deutsche medizinische Wochenschrift·Inga JaroschAndreas Rembert Koczulla
Nov 30, 2021·Expert Opinion on Investigational Drugs·Giacomo SgallaLuca Richeldi
Dec 4, 2021·The European Respiratory Journal·Claudia ValenzuelaGanesh Raghu
Nov 6, 2021·The European Respiratory Journal·Kathleen JahnKatrin E Hostettler
Jan 21, 2022·Journal of the American Heart Association·Charlotte B IngulTorstein Jensen
Dec 2, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sabina SahanicJudith Loeffler-Ragg

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT04416100

Software Mentioned

via
R
SPSS Statistics
Syngo
CT Pneumonia Analysis

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