Jun 24, 2006

Cardiopulmonary resuscitation in a rat model of chronic myocardial ischemia

Journal of Applied Physiology
Xiangshao FangMax Harry Weil


Our group has developed a rat model of cardiac arrest and cardiopulmonary resuscitation (CPR). However, the current rat model uses healthy adult animals. In an effort to more closely reproduce the event of cardiac arrest and CPR in humans with chronic coronary disease, a rat model of coronary artery constriction was investigated during cardiac arrest and CPR. Left coronary artery constriction was induced surgically in anesthetized, mechanically ventilated Sprague-Dawley rats. Echocardiography was used to measure global cardiac performance before surgery and 4 wk postsurgery. Coronary constriction provoked significant decreases in ejection fraction, increases in left ventricular end-diastolic volume, and increases left ventricular end-systolic volume at 4 wk postintervention, just before induction of ventricular fibrillation (VF). After 6 min of untreated VF, CPR was initiated on three groups: 1) coronary artery constriction group, 2) sham-operated group, and 3) control group (without preceding surgery). Defibrillation was attempted after 6 min of CPR. All the animals were resuscitated. Postresuscitation myocardial function as measured by rate of left ventricular pressure increase at 40 mmHg and the rate of left ventricular pres...Continue Reading

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Mentioned in this Paper

Ventricular Fibrillation
Salicylhydroxamic acid
Left Ventricle Remodeling
Ventricular Dysfunction, Left
Myocardial Dysfunction
Basic Cardiac Life Support
Myocardial Ischemia
Left Coronary Artery Structure
Entire Coronary Artery

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