PMID: 6115907Apr 1, 1981Paper

Cardioregulatory properties of indoramin in the rat

The Journal of Pharmacy and Pharmacology
D R AlgateJ F Waterfall

Abstract

The antihypertensive action of the competitive alpha-adrenoceptor antagonist indoramin is not accompanied by reflex tachycardia in animals or man. The possibility that the established local anaesthetic property of indoramin is involved in its cardioinhibitory action has been investigated. Indoramin evoked a dose-dependent bradycardia in anaesthetized/pithed rats. The decrease in heart rate was slightly greater than that evoked in anaesthetized intact animals suggesting that indoramin had a direct action on the heart. Reflex tachycardia was simulated in pithed rats be increasing the frequency of cardiac nerve stimulation from 0.3 to 1 Hz. Indoramin and the local anaesthetic agents, lignocaine and procaine, reduced the positive chronotropic response without markedly altering the basal rate. The response curves were parallel. In contrast, phentolamine decreased the positive chronotropic response, but only at high doses which were associated with a marked decrease in the basal rate. Thymoxamine and prazosin had so significant effects on the chronotropic response. These experiments suggest that the cardioregulatory action of indoramin is attributable to its local anaesthetic property had this action further distinguishes it from the...Continue Reading

References

Oct 1, 1978·The Journal of Pharmacy and Pharmacology·D R Algate, J F Waterfall
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·M A CommaratoH R Kaplan
Jan 1, 1974·Current Medical Research and Opinion·R CarballoJ Suarez
Sep 1, 1971·The Journal of Pharmacy and Pharmacology·B J AlpsA B Wilson
Jul 1, 1973·Japanese Heart Journal·J Iriuchijima

Citations

Nov 27, 1984·European Journal of Pharmacology·A G Ramage
Jan 1, 1983·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·M J Kendall, S R Smith
Apr 1, 1988·British Journal of Clinical Pharmacology·A H DeeringR G Shanks
Jun 1, 1984·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Feb 1, 1986·British Journal of Pharmacology·V PierceJ F Waterfall

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