Cardiorespiratory control and cytokine profile in response to heat stress, hypoxia, and lipopolysaccharide (LPS) exposure during early neonatal period

Physiological Reports
Fiona B McDonaldShabih U Hasan

Abstract

Sudden infant death syndrome (SIDS) is one of the most common causes of postneonatal infant mortality in the developed world. An insufficient cardiorespiratory response to multiple environmental stressors (such as prone sleeping positioning, overwrapping, and infection), during a critical period of development in a vulnerable infant, may result in SIDS. However, the effect of multiple risk factors on cardiorespiratory responses has rarely been tested experimentally. Therefore, this study aimed to quantify the independent and possible interactive effects of infection, hyperthermia, and hypoxia on cardiorespiratory control in rats during the neonatal period. We hypothesized that lipopolysaccharide (LPS) administration will negatively impact cardiorespiratory responses to increased ambient temperature and hypoxia in neonatal rats. Sprague-Dawley neonatal rat pups were studied at postnatal day 6-8. Rats were examined at an ambient temperature of 33°C or 38°C. Within each group, rats were allocated to control, saline, or LPS (200 μg/kg) treatments. Cardiorespiratory and thermal responses were recorded and analyzed before, during, and after a hypoxic exposure (10% O2). Serum samples were taken at the end of each experiment to measure...Continue Reading

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Citations

Sep 8, 2017·Canadian Journal of Physiology and Pharmacology·Fiona B McDonaldShabih U Hasan
Jul 14, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karlene T BarrettRichard J A Wilson
Oct 14, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fiona B McDonaldShabih U Hasan
Feb 14, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karlene T BarrettRichard J A Wilson
Oct 19, 2019·Experimental Physiology·Fiona B McDonaldKen D O'Halloran
Jul 18, 2019·Respiratory Physiology & Neurobiology·Andrew M Dylag, Thomas M Raffay
Oct 16, 2019·Respiratory Physiology & Neurobiology·Nina R MorrisonAdrianne G Huxtable
Nov 5, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karlene T BarrettRichard J A Wilson

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Methods Mentioned

BETA
Assay

Software Mentioned

Grubbs
AxoScope
GraphPad Prism
LabChart

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