PMID: 9442252Jan 27, 1998Paper

Cardiorespiratory effects of sevoflurane, isoflurane, and halothane anesthesia in horses

American Journal of Veterinary Research
D A Grosenbaugh, W W Muir

Abstract

To determine and compare cardiorespiratory and recovery effects of sevoflurane, isoflurane, and halothane in horses. 8 clinically normal horses (4 mares, 4 geldings), 5 to 12 years old. Inhalation anesthesia was maintained for 90 minutes with sevoflurane, isoflurane, or halothane. Anesthesia depth was maintained at 1.5 minimum alveolar concentration of halothane, isoflurane, and sevoflurane, then was reduced at 30 and 60 minutes. A surgical plane of anesthesia was reinduced by administration of ketamine or thiopental or by increasing the fractional inspired concentration of sevoflurane. Cardiovascular and pulmonary variables were recorded and compared among inhalation anesthetics. Recovery was monitored, and subjective assessment of recovery quality was performed. Hemodynamic and pulmonary indices during sevoflurane anesthesia were similar to those of isoflurane. Cardiac output and systemic arterial pressure decreased less during sevoflurane and isoflurane anesthesia than during halothane anesthesia. After 90 minutes, cardiac output was greater for sevoflurane and isoflurane, respectively, compared with halothane. Mean arterial pressure was similar for all three anesthetic agents. Respiratory rate for sevoflurane and isoflurane...Continue Reading

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