Abstract
Previous studies have found positive associations between cardiorespiratory fitness (CRF) and cognitive performance in older people but data are inconsistent and have methodological limitations. Our aim was to study the longitudinal associations of CRF with executive functions, processing speed and memory as well as with the overall cognitive function in older people at risk for cognitive impairment. Participants (n = 421), mean age 69.0, were a sub-sample of The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). To be eligible, individuals were required to be 60-77 years old with a CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Dementia Risk Score of at least 6 points and cognition at mean level or slightly lower than expected for age. CRF was assessed as peak oxygen uptake (VO2peak, L/min) measured directly in a symptom-limited maximal exercise test on cycle ergometer at baseline and at 24 months. Cognitive performance was assessed using an extensive neuropsychological test battery (NTB) at baseline and at 24 months. NTB data were standardized to Z scores, and analyzed with the linear mixed model. Over two years, VO2peak was associated with NTB total score (β= 0.12, p = 0.01...Continue Reading
References
Sep 1, 1989·Neurology·J C MorrisC Clark
Mar 27, 2003·Journal of the American Geriatrics Society·Deborah E BarnesIra B Tager
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Jul 11, 2006·Journal of Clinical and Experimental Neuropsychology·Rachel S Newson, Eva B Kemps
May 23, 2007·International Journal of Circumpolar Health·Timo SaaristoUNKNOWN FIN-D2D Study Group
Sep 12, 2007·Archives of Neurology·John HarrisonMichael Grundman
Mar 5, 2008·Alzheimer Disease and Associated Disorders·Jeffrey M BurnsJoseph E Donnelly
Dec 30, 2008·Neurobiology of Aging·Allison D BrownMarc J Poulin
Dec 5, 2009·International Journal of Epidemiology·Erkki VartiainenPekka Puska
Jun 23, 2010·International Psychogeriatrics·Yael NetzRuth Agmon
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Dec 17, 2011·Brain, Behavior, and Immunity·Andrea M WeinsteinKirk I Erickson
Jan 22, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miia KivipeltoHilkka Soininen
Feb 6, 2013·Annals of Internal Medicine·Laura F DefinaJarett D Berry
Nov 7, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carrington R WendellAlan B Zonderman
Sep 12, 2014·International Journal of Environmental Research and Public Health·Tiia NganduMiia Kivipelto
Oct 14, 2014·Neurobiology of Aging·Claudine Joëlle GauthierRichard D Hoge
Nov 12, 2014·BMC Medicine·Renée F A G de Bruijn, M Arfan Ikram
Dec 22, 2014·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Scott M HayesMieke Verfaellie
Jun 2, 2015·American Heart Journal·Aharon ErezElad Maor
Nov 20, 2015·Journal of the International Neuropsychological Society : JINS·Stephanie A SchultzOzioma C Okonkwo
Jan 8, 2016·Neurology·Paul FreudenbergerHelena Schmidt
Nov 26, 2016·International Journal of Cardiology·Meghan K Edwards, Paul D Loprinzi
Mar 16, 2017·Brain and Behavior·Ryan J DoughertyDane B Cook
Citations
May 15, 2020·Neurology·Veronica GuadagniMarc J Poulin
May 28, 2020·Aging Clinical and Experimental Research·Katie PalmerShaantanu Donde
Nov 19, 2019·Frontiers in Psychology·Fabian HeroldNotger G Müller
Jan 24, 2020·Brain Plasticity·Jamie C PevenKirk I Erickson
Jan 24, 2020·Brain Plasticity·Patrick J Smith
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Patrick J SmithJames A Blumenthal
Nov 27, 2020·Frontiers in Physiology·Stephanie A SchultzManu S Goyal
Jan 30, 2021·Scientific Reports·Peter E WaisAdam Gazzaley
Dec 18, 2020·Frontiers in Psychiatry·Gianfranco SpallettaKatie Palmer
May 1, 2021·Healthcare·Suh-Jung KangJinsung Wang
Jul 17, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ryan J DoughertyDane B Cook
Sep 14, 2021·Journal of the American Heart Association·Goretti España-IrlaÁlvaro Pascual-Leone
Nov 26, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ryan J DoughertyDane B Cook