Cardiorespiratory fitness and incident diabetes: the FIT (Henry Ford ExercIse Testing) project

Diabetes Care
Stephen P JuraschekMouaz H Al-Mallah

Abstract

Prior evidence has linked higher cardiorespiratory fitness with a lower risk of diabetes in ambulatory populations. Using a demographically diverse study sample, we examined the association of fitness with incident diabetes in 46,979 patients from The Henry Ford ExercIse Testing (FIT) Project without diabetes at baseline. Fitness was measured during a clinician-referred treadmill stress test performed between 1991 and 2009. Incident diabetes was defined as a new diagnosis of diabetes on three separate consecutive encounters derived from electronic medical records or administrative claims files. Analyses were performed with Cox proportional hazards models and were adjusted for diabetes risk factors. The mean age was 53 years with 48% women and 27% black patients. Mean metabolic equivalents (METs) achieved was 9.5 (SD 3.0). During a median follow-up period of 5.2 years (interquartile range 2.6-8.3 years), there were 6,851 new diabetes cases (14.6%). After adjustment, patients achieving ≥12 METs had a 54% lower risk of incident diabetes compared with patients achieving <6 METs (hazard ratio 0.46 [95% CI 0.41, 0.51]; P-trend < 0.001). This relationship was preserved across strata of age, sex, race, obesity, hypertension, and hyperl...Continue Reading

References

Dec 1, 1987·Journal of Applied Physiology·D S KingJ O Holloszy
Apr 1, 1985·Journal of the American Geriatrics Society·C B HollenbeckG M Reaven
Jun 1, 1995·Medicine and Science in Sports and Exercise·J G RegensteinerW R Hiatt
Mar 24, 1998·Annual Review of Medicine·L J Goodyear, B B Kahn
Jul 20, 2002·Medicine and Science in Sports and Exercise·Rob M Van DamDaan Kromhout
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Dec 18, 2003·JAMA : the Journal of the American Medical Association·Mercedes R CarnethonKiang Liu
Jun 29, 2005·Diabetes Care·Zhi You FangThomas H Marwick
May 2, 2006·Journal of the American Dietetic Association·Carrie E FinleyMilton Z Nichaman
May 8, 2008·Medicine and Science in Sports and Exercise·Paul T Williams
Sep 20, 2008·Diabetologia·J Szendroedi, M Roden
Aug 7, 2009·British Journal of Sports Medicine·John C SieverdesSteven N Blair
Nov 17, 2009·Diabetes Research and Clinical Practice·Gojka Roglic, Nigel Unwin
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Jun 28, 2011·Metabolism: Clinical and Experimental·Filip J LarsenThomas Nyström
Nov 2, 2013·Annals of Epidemiology·Stephen P JuraschekJ Hunter Young
Jan 1, 2014·Progress in Molecular Biology and Translational Science·Jinzeng Yang
Aug 21, 2014·Clinical Cardiology·Mouaz H Al-MallahMichael J Blaha

❮ Previous
Next ❯

Citations

Jan 2, 2016·The American Journal of Cardiology·Sae Young JaeWon Hah Park
May 8, 2016·The American Journal of Medicine·Paul A McAuleyMouaz H Al-Mallah
May 18, 2016·Journal of Cardiopulmonary Rehabilitation and Prevention·Sherrie KhadangaPhilip A Ades
Dec 13, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Benjamin J GrayUNKNOWN Prosiect Sir Gâr Group
Mar 2, 2017·American Journal of Respiratory and Critical Care Medicine·Lillian R BenckRavi Kalhan
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Oct 24, 2018·Clinical Cardiology·Ahmed Abu-HaniyehHaitham M Ahmed
Jan 18, 2018·Current Atherosclerosis Reports·Mouaz H Al-MallahAda Al-Qunaibet
Feb 2, 2018·The European Respiratory Journal·Luis Puente-Maestu, William W Stringer
Sep 4, 2019·Medicine and Science in Sports and Exercise·Robert L NewtonTimothy S Church
Aug 30, 2020·European Heart Journal·Antonio PellicciaUNKNOWN ESC Scientific Document Group
May 22, 2018·Frontiers in Endocrinology·Jürgen Harreiter, Alexandra Kautzky-Willer
Jul 31, 2018·Pediatric Blood & Cancer·Carmen L WilsonKirsten K Ness
Mar 19, 2021·Sports Health·Alec J MoormanJonathan A Drezner

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

© 2021 Meta ULC. All rights reserved