Cardiorespiratory fitness and muscle strength in pancreatic cancer patients

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Dorothea ClaussKaren Steindorf

Abstract

Cancer patients frequently experience reduced physical fitness due to the disease itself as well as treatment-related side effects. However, studies on physical fitness in pancreatic cancer patients are missing. Therefore, we assessed cardiorespiratory fitness and muscle strength of pancreatic cancer patients. We included 65 pancreatic cancer patients, mostly after surgical resection. Cardiorespiratory fitness was assessed using cardiopulmonary exercise testing (CPET) and 6-min walk test (6MWT). Hand-held dynamometry was used to evaluate isometric muscle strength. Physical fitness values were compared to reference values of a healthy population. Associations between sociodemographic and clinical variables with patients' physical fitness were analyzed using multiple regression models. Cardiorespiratory fitness (VO2peak, 20.5 ± 6.9 ml/min/kg) was significantly lower (-24%) compared to healthy reference values. In the 6MWT pancreatic cancer patients nearly reached predicted values (555 vs. 562 m). Maximal voluntary isometric contraction (MVIC) of the upper (-4.3%) and lower extremities (-13.8%) were significantly lower compared to reference values. Overall differences were larger in men than those in women. Participating in regula...Continue Reading

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Citations

Sep 29, 2017·Current Opinion in Supportive and Palliative Care·Egidio Del FabbroSusan M Stella
Aug 8, 2020·The Tohoku Journal of Experimental Medicine·Yukio MikamiHiroki Yamaue
Mar 30, 2020·Journal of Cancer Survivorship : Research and Practice·Linda O'NeillJuliette Hussey
May 6, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Matthias LimbachJoachim Wiskemann
Nov 28, 2020·European Journal of Cancer Care·Yuki NakashimaHitoshi Okamura
Jul 25, 2020·International Journal of Sports Medicine·Anasua PalKaren Steindorf
Oct 13, 2021·Experimental Gerontology·Nicholas HarmanReid Hayward
Feb 23, 2022·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Priti GuptaEmily C LaVoy

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