Cardiorespiratory fitness reduces the risk of incident hypertension associated with a parental history of hypertension

Hypertension
Robin P ShookSteven N Blair

Abstract

Family history of hypertension increases the risk of an individual to develop hypertension, whereas moderate-to-high cardiorespiratory fitness has the opposite effect. However, the joint association of each on the development of hypertension is not well understood. We studied fitness and incident hypertension in 6278 participants who were given a preventative medical examination. Thirty-three percent reported a parent with hypertension, and there were 1545 cases of incident hypertension after a mean of 4.7 years. The presence of parental hypertension was associated with a 28% higher risk of developing hypertension after adjustments for age, sex, and examination year. After further adjustments for smoking, alcohol intake, resting systolic and diastolic blood pressures, hypercholesterolemia, body mass index, physical inactivity, and fitness, there was a 20% higher risk associated with parental hypertension. After adjusting for age, sex, and examination year, both moderate and high levels of fitness were associated with lower risk for developing hypertension by 26% and 42%, respectively. In the joint analysis, individuals with both a low level of fitness and a parent with hypertension exhibited a 70% higher risk for developing hyp...Continue Reading

References

Sep 1, 1979·American Journal of Epidemiology·R J HavlikP M McNamara
Jan 1, 1986·Journal of Chronic Diseases·S C HuntG K Barlow
Jul 27, 1984·JAMA : the Journal of the American Medical Association·S N BlairK H Cooper
Mar 1, 1983·American Journal of Epidemiology·R S PaffenbargerD L Jung
Jan 1, 1993·American Journal of Hypertension·M F MuldoonS B Manuck
Jan 24, 1998·Annals of Internal Medicine·Z HuangG A Colditz
Apr 3, 2002·Annals of Internal Medicine·Seamus P WheltonJiang He
Oct 17, 2002·JAMA : the Journal of the American Medical Association·Paul K WheltonUNKNOWN National High Blood Pressure Education Program Coordinating Committee
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Mar 28, 2007·American Journal of Hypertension·Rebecca P GelberHoward D Sesso
Oct 3, 2007·Medicine and Science in Sports and Exercise·Tuomo RankinenSteven N Blair
Dec 20, 2007·Medicine and Science in Sports and Exercise·Richard P TroianoMargaret McDowell
Apr 26, 2008·American Journal of Hypertension·Sara L ShugerSteven N Blair
Jul 29, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Pamela M M DodrillUNKNOWN OZGROW Advisory Committee of the Australasian Paediatric Endocrine Group
Mar 17, 2011·American Journal of Preventive Medicine·Jared M TuckerNicholas K Beyler

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Citations

Mar 23, 2013·Current Hypertension Reports·Fernanda R RoqueAna M Briones
Sep 21, 2013·Current Hypertension Reports·Keith M Diaz, Daichi Shimbo
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xin-Fang LeongKamsiah Jaarin
Sep 23, 2014·Journal of the American College of Cardiology·Junxiu LiuSteven N Blair
Apr 19, 2015·The American Journal of Cardiology·Sae Young JaeBarry A Franklin
Dec 3, 2014·International Journal of Cardiology·Sanja MazicSlavica Suzic
Feb 26, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lene A H HaakstadKari Bø
Jul 22, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Milica DeklevaSanja Mazic
Oct 19, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sae Young JaeJari A Laukkanen
Apr 22, 2017·European Heart Journal·Teemu J NiiranenSusan Cheng
Dec 19, 2014·Journal of the American Heart Association·Stephen P JuraschekMouaz H Al-Mallah
Oct 26, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuko GandoSteven N Blair
Sep 3, 2013·Physiology·Carmen Fiuza-LucesAlejandro Lucia

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