PMID: 9531452Apr 8, 1998Paper

Cardiorespiratory reflexes in mice

Journal of the Autonomic Nervous System
J F Paton, J W Butcher

Abstract

The various transgenic strains of mice make this species an attractive experimental model. We compared qualitatively some cardiorespiratory reflexes in two different preparations of mouse: in vivo urethane anaesthetised and a working heart-brainstem preparation (WHBP). Cardiorespiratory reflexes were evoked by stimulating baroreceptors, pulmonary vagal C fibres and cardiac receptors in both preparations, while peripheral chemoreceptors were also stimulated in the WHBP. In anaesthetised mice, activation of baroreceptors, pulmonary C fibres and cardiac receptors evoked an atropine-sensitive bradycardia (range: 21-414 bts/min) and depressed ventilation. A reflex fall in arterial pressure was also observed during pulmonary C fibre and cardiac receptor stimulation. Similar reflex bradycardia (range 81-164 bts/min) and respiratory responses were observed in the WHBP following stimulation of baro-, pulmonary C fibre and cardiac receptors. Additionally, sodium cyanide stimulation of peripheral chemoreceptors in the WHBP produced an atropine-sensitive bradycardia and increased respiratory frequency and amplitude. Thus, the cardiorespiratory reflex responses elicited in the mouse are similar to those reported in other species. It is conc...Continue Reading

References

May 1, 1988·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·S M TuttR Hainsworth
Jan 1, 1973·Physiological Reviews·A S Paintal
Jan 1, 1984·Reviews of Physiology, Biochemistry and Pharmacology·J C Coleridge, H M Coleridge
Mar 1, 1996·Journal of Neuroscience Methods·J F Paton
Aug 1, 1997·Pflügers Archiv : European journal of physiology·S Kasparov, J F Paton
Mar 1, 1965·The Journal of Physiology·A M BROWN

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Citations

Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·P Boscan, J F Paton
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·J E SmithP L Andrews
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Xiuying MaMark W Chapleau
Jan 3, 2001·Journal of Molecular and Cellular Cardiology·B D Hoit
Jun 26, 2010·Heart Failure Reviews·Mark W Chapleau, Rasna Sabharwal
Apr 12, 2015·Journal of Neuroscience Methods·Melissa M J FarnhamPaul M Pilowsky
Dec 14, 2011·Respiratory Physiology & Neurobiology·W Michael PannetonD Wei Sun
Sep 23, 2016·The Journal of Physiology·David G S FarmerRobin M McAllen
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
Sep 21, 2010·American Journal of Physiology. Heart and Circulatory Physiology·R M LataroR Fazan
Apr 1, 2006·Journal of Applied Physiology·Rurong Wang, Fadi Xu
Feb 13, 2001·Journal of Applied Physiology·J M KramerT G Waldrop
Aug 5, 2000·Journal of Applied Physiology·F P Tolentino-SilvaI A Dreshaj
Dec 17, 2002·Journal of Applied Physiology·Fadi XuLu-Yuan Lee
Jan 28, 2021·Experimental Physiology·Karla L RodriguesBenedito H Machado

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