PMID: 2861218Jul 1, 1985Paper

Cardioselective and nonselective beta-adrenoceptor blocking drugs in hypertension: a comparison of their effect on blood pressure during mental and physical activity

Journal of the American College of Cardiology
J S FlorasP Sleight

Abstract

The ability of cardioselective and nonselective beta-adrenoceptor blocking drugs, with and without partial agonist activity, to control increases in blood pressure associated with mental and physical activity was compared in 35 subjects with hypertension. Direct measurements of blood pressure and radioenzymatic determinations of plasma norepinephrine were obtained before, during and after four activities, and were repeated after random allocation to treatment with atenolol, metoprolol, pindolol or propranolol. Cardioselective and nonselective drugs modestly reduced the pressor response to reaction time testing, but not to mental arithmetic or isometric exercise. The increase in systolic blood pressure during bicycling was attenuated significantly by the cardioselective drugs atenolol (by 23 mm Hg, or 38%) and metoprolol (21 mm Hg, or 41%), but not by the nonselective agents pindolol (with partial agonist activity) (13 mm Hg, or 20%) and propranolol (10 mm Hg, or 17%) (p less than 0.02 cardioselective versus nonselective; p = NS pindolol versus propranolol). Only bicycle exercise increased plasma norepinephrine concentrations (by 80%). These results suggest that beta-adrenoceptor blocking drugs will not attenuate increases in bl...Continue Reading

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Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·H RüddelH Schächinger
Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank
Dec 1, 1988·Journal of the Autonomic Nervous System·J S FlorasP Sleight
Oct 1, 1992·Journal of the American Academy of Nurse Practitioners·M M Swenson
May 3, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Moritz MeuselFriedhelm Sayk
May 16, 2002·Journal of Hypertension·J S Floras
Mar 27, 2018·Sports Medicine·Katharine D CurrieJack M Goodman
Mar 1, 1989·The Journal of International Medical Research·Y KobayashiN Kajiwara
Apr 16, 2021·International Journal of Hypertension·Marcus Vinicius MachadoAntonio Claudio Lucas da Nóbrega

Related Concepts

Adrenergic beta-Antagonists
Tenormin
Bicycling (Recreational Activity)
Diastolic Blood Pressure
Hypertensive Disease
Isometric Contraction
Mathematics
Betalok
Visken
Rexigen

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