Cardiothoracic manifestations of neuroendocrine tumours

The British Journal of Radiology
Ramin MandegaranNicholas Screaton

Abstract

Cardiothoracic neuroendocrine tumour (NET) manifestations encompass a vast disease spectrum. Pulmonary neuroendocrine tumours represent a range of tumour grade and differentiation characteristics from pre-malignant diffuse neuroendocrine cell hyperplasia, well-differentiated, low-grade carcinoid tumours with excellent outcomes, through to high-grade small-cell lung carcinoma and large-cell neuroendocrine carcinoma with poor prognoses. Rarer thymic NETs represent a similarly wide neoplastic spectrum. Cardiac carcinoid is a paraneoplastic manifestation of the carcinoid syndrome and often the cause of mortality in NETs with hepatic metastases. Cardiothoracic NET manifestations are reviewed herein from a radiologists' perspective, discussing the diverse clinical presentations, spectrum of neoplastic and paraneoplastic manifestations, imaging features and treatment options.

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Citations

Apr 28, 2017·Journal of Computer Assisted Tomography·Xiaojing KanYinghui Ge
Oct 8, 2018·Reviews in Endocrine & Metabolic Disorders·Sergio Pedraza-ArévaloJusto P Castaño
Nov 27, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yuhua YangShengcai Huang

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