Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one

Circulation Research
A A AlousiC J Opalka


The cardiotonic activity of a new, noncatechol, nonglycoside agent, amrinone, was investigated in vitro and in anesthestized and unanesthetized dogs. Amrinone (3-100 microgram/ml) caused a dose-dependent increase in papillary muscle developed tension and df/dt without significant changes in duration of the contractile cycle or time-to-peak tension. Amrinone induced slight increases in right atrial rate with no changes in electrophysiological properties of the cat papillary muscle or dog Purkinje fibers. In anesthetized dogs, intravenous bolus injections of amrinone at doses ranging from 1 to 10 mg/kg caused increases in cardiac contractile force and left ventricular dp/dt max with relatively small changes in heart rate and blood pressure. No significant changes in lead II ECG were observed. In unanesthetized dogs, intravenous infusion of amrinone (10-100 microgram/kg per min) caused increases in left ventricular dp/dt max and only small changes in heart rate and blood pressure. Amrinone, tested orally in this model at doses of 2-10 mg/kg, produced a positive inotropic effect with a rapid onset and long duration of action. The inotropic response to amrinone was not blocked by propranolol, dibenzyline, chlorisondamine, atropine, ...Continue Reading


Jul 7, 1977·The New England Journal of Medicine·J N Cohn, J A Franciosa
Dec 5, 1977·JAMA : the Journal of the American Medical Association·J Mehta
Apr 3, 1978·Life Sciences·A E Farah, A A Alousi
Dec 21, 1978·The New England Journal of Medicine·J R BenottiA A Alousi
Jan 1, 1975·Annual Review of Medicine·J E Doherty, J J Kane
May 1, 1971·The American Journal of Cardiology·D T MasonE A Amsterdam
Oct 3, 1974·The New England Journal of Medicine·L I Goldberg
Nov 16, 1973·Life Sciences·R Parvin, N Kalant
May 1, 1974·American Heart Journal·J BeregovichB Levitt
Aug 1, 1968·The American Journal of Cardiology·L I Goldberg
May 6, 1971·The New England Journal of Medicine·G A BellerW B Hood
Sep 1, 1957·The American Journal of Physiology·B F HOFFMANE E SUCKLING
Feb 4, 1958·Acta Physiologica Scandinavica·E BERGLUNDG L SCHREINER
Dec 1, 1963·Biochemical Pharmacology·R J WURTMAN, J AXELROD
May 1, 1960·Biochemical Pharmacology·W H PRUSOFFH GUNTHER
Jun 1, 1950·The American Journal of Physiology·R P WALTONP C GAZES


Jun 13, 2002·Clinical Cardiology·Arthur M Feldman, Dennis M McNamara
Nov 1, 1995·Journal of Clinical Pharmacology·K HaradaA Fujimura
Apr 1, 1990·Cardiovascular Drugs and Therapy·P DorigoI Maragno
Jan 1, 1994·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·Y KesimN Banoglu
May 18, 2007·Cardiovascular Drugs and Therapy·Masao Endoh
Sep 1, 1981·American Heart Journal·R E RudeE Braunwald
Sep 1, 1984·The American Journal of Cardiology·G V NaccarelliR A Goldstein
Dec 17, 1985·European Journal of Pharmacology·R E WeishaarD B Evans
May 13, 1986·European Journal of Pharmacology·E Vigholt Sørensen, F Nielsen-Kudsk
Jan 1, 1982·Pharmacology & Therapeutics·D B EvansH R Kaplan
Jun 1, 1983·Prostaglandins, Leukotrienes, and Medicine·E L KinneyL M Demers
Jan 1, 1982·General Pharmacology·W E Glover
Sep 1, 1995·Progress in Cardiovascular Diseases·J E TisdaleB J Zarowitz
Nov 1, 1983·Journal of the American College of Cardiology·M Packer
Feb 1, 1984·Journal of the American College of Cardiology·J P MorganH V Schaff
May 1, 1984·Journal of the American College of Cardiology·M LikoffM L Rocci
Aug 1, 1984·Journal of the American College of Cardiology·H Scholz
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K M MylotteM Schoenl
Apr 1, 1991·Acta Anaesthesiologica Scandinavica·C RanerO Winsö
Mar 1, 1984·Acta Physiologica Scandinavica·Alf Månsson, K A Edman
Nov 1, 1985·Acta Physiologica Scandinavica·Alf Månsson, K A Edman
May 1, 1989·Acta Physiologica Scandinavica·Alf MånssonK A Edman
Jun 1, 1990·Acta Physiologica Scandinavica·S E Morner, Alf Månsson
Aug 1, 1990·Acta Physiologica Scandinavica·S E Morner, B Wohlfart
Oct 1, 1987·Journal of Veterinary Internal Medicine·G G KnowlenM D Kittleson
Jan 1, 1983·British Heart Journal·P T WilmshurstM M Webb-Peploe
Aug 1, 1980·The Journal of Clinical Investigation·J C Parker, J R Harper
Jan 1, 1983·Intensive Care Medicine·R Hayward
Jan 1, 1990·Intensive Care Medicine·M BernerB Friedli
Jun 1, 1982·Journal of Pharmacological Methods·O G Beek
Jan 16, 1999·Journal of Cardiovascular Pharmacology·T KerttulaS Kaukinen
Apr 29, 1998·Journal of Cardiovascular Pharmacology·H AtarashiH Hayakawa
Jan 1, 1992·Critical Reviews in Toxicology·P DogteromG K Reznik
Jan 1, 1994·Journal of Toxicology. Clinical Toxicology·S SatoH Naito
Jun 1, 1991·American Heart Journal·P Honerjäger
Dec 1, 1984·The American Journal of Cardiology·B G FirthL D Hillis
Jan 1, 1981·Prostaglandins and Medicine·G H RaoJ G White
Oct 9, 2004·The Journal of Veterinary Medical Science·Denji TobataNobuo Sasaki
Sep 1, 1991·The Veterinary Clinics of North America. Small Animal Practice·C A Calvert
Feb 26, 2013·PloS One·Malin PerssonArmagan Kocer
Aug 1, 1983·The American Journal of Cardiology·C V LeierD V Unverferth
Sep 8, 2004·Journal of Molecular and Cellular Cardiology·Rumi MasunagaMitsuyasu Itoh
Dec 1, 1982·European Journal of Clinical Investigation·H PouleurG Mancia
Jan 3, 1989·The American Journal of Cardiology·G V Naccarelli, R A Goldstein
Nov 1, 1984·Archives internationales de physiologie et de biochimie·D el AllafJ Carlier
Jul 1, 1983·Medicinal Research Reviews·J A Bristol, D B Evans
Oct 1, 1985·Journal of Clinical Pharmacology·D M ManciniE H Sonnenblick
Oct 1, 1984·Clinical Cardiology·D Levene, R A Secter
Oct 10, 1997·Anesthesia and Analgesia·T PernerstorferH G Eichler
Apr 1, 1986·British Journal of Pharmacology·P Dorigo, I Maragno
Jul 1, 1983·Journal of Clinical Pharmacology·A NusratR S Aronson
Feb 1, 1993·Journal of Muscle Research and Cell Motility·R BottinelliC Reggiani
Jan 1, 1982·The Journal of Pharmacy and Pharmacology·Y IshidaS Shibata
Oct 1, 1995·Clinical and Experimental Immunology·T HirozaneS Sasayama
Aug 1, 1986·British Journal of Pharmacology·K Hashimoto, H Mitsuhashi
Sep 1, 1995·Equine Veterinary Journal. Supplement·W W Muir
Oct 1, 1982·Journal of Clinical Pharmacology·E L KinneyR Zelis

Related Concepts

Cyclic AMP, (R)-Isomer
DNA-dependent ATPase
Adrenergic beta-Antagonists
Anesthesia Procedures
Diastolic Blood Pressure
Cardiotonic Agents
Felis catus
Canis familiaris

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.