Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats

American Journal of Physiology. Heart and Circulatory Physiology
Na ZhaoJing-Yan Han

Abstract

Cardiotonic pills (CP) is a compound Chinese medicine widely used in China, as well as other countries, for the treatment of cardiovascular disease. However, limited data are available regarding the mechanism of action of CP on myocardial function during ischemia-reperfusion (I/R) injury. In this study, we examined the effect of CP on I/R-induced coronary microcirculatory disturbance and myocardial damage. Male Sprague-Dawley rats were subjected to left coronary anterior descending branch occlusion for 30 min followed by reperfusion with or without pretreatment with CP (0.1, 0.4, or 0.8 g/kg). Coronary blood flow, vascular diameter, velocity of red blood cells, and albumin leakage were evaluated in vivo after reperfusion. Neutrophil expression of CD18, malondialdehyde, inhibitor-kappaBalpha, myocardial infarction, endothelial expression of intercellular adhesion molecule 1, apoptosis-related proteins, and histological and ultrastructural evidence of myocardial damage were assessed after reperfusion. Pretreatment with CP (0.8 g/kg) significantly attenuated the I/R-induced myocardial microcirculatory disturbance, including decreased coronary blood flow and red blood cell velocity in arterioles, increased expression of CD18 on neu...Continue Reading

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Citations

Oct 4, 2011·Biological & Pharmaceutical Bulletin·Yiqun TangYuemiao Yin
Aug 24, 2012·Journal of Geriatric Cardiology : JGC·Zhuo LiangYa-Ling Han
Nov 13, 2010·World Journal of Gastroenterology : WJG·Ming-Xia WangJing-Yan Han
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Aug 24, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Xiao-Hong WeiJing-Yan Han
Sep 12, 2015·BMC Complementary and Alternative Medicine·Li-Na GaoShan Gao
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Duan-Yong LiuJing-Yan Han
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Xin TangPing-Ping Li
Jul 22, 2011·Atherosclerosis·Si GaoSuowen Xu
Nov 22, 2012·International Journal of Cardiology·Se-Qi LinJing-Yan Han
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Yuan YangJing-Yan Han
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May 3, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·Joan DowRobert A Kloner
Mar 29, 2019·Oxidative Medicine and Cellular Longevity·Xinyu YangHongcai Shang
Nov 16, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chong LiJing-Yan Han
Oct 12, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Ke HeJing-Yan Han
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenjing LiaoHe Sun

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