Cardiotoxic effects of venom fractions from the Australian box jellyfish Chironex fleckeri on human myocardiocytes

Toxicon : Official Journal of the International Society on Toxinology
Silvia L A Saggiomo, Jamie E Seymour

Abstract

An investigation into the cardiotoxic effects in human cardiomyocytes of different fractions (as produced from an FPLC) of the venom from Chironex fleckeri showed that whole venom caused cardiac cell death in minutes, measured as cell detachment using xCELLigence technology. However, only one fraction of the venom was responsible for this effect. When all extracted venoms were recombined a similar result was seen for the toxic fraction, however these effects were slower than unfractionated venom alone even though the concentrations were similar. The difference in the results between fractioned and unfractionated venom may have been caused by compounds remaining in the FPLC column, which may interact with the toxic fraction to cause rapid cell detachment or death.

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Citations

Aug 28, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Athena AndreossoJamie E Seymour
Oct 7, 2014·Toxicon : Official Journal of the International Society on Toxinology·Sophie Badré
Feb 26, 2013·Marine Drugs·Luca CegolonGiuseppe Mastrangelo
Nov 6, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xiaosheng QuWei Shu
Sep 20, 2015·Toxicon : Official Journal of the International Society on Toxinology·Dalia PonceJuan José Dorantes-Aranda
Nov 2, 2013·Toxicon : Official Journal of the International Society on Toxinology·Peter Pereira, Jamie E Seymour
Jan 28, 2014·Toxicon : Official Journal of the International Society on Toxinology·Stephanie ChaousisJamie Seymour
Sep 27, 2012·Toxicon : Official Journal of the International Society on Toxinology·S McClounan, J Seymour
Jan 23, 2018·Toxicon : Official Journal of the International Society on Toxinology·Vanessa NealeJamie E Seymour
Jul 3, 2020·Toxicon : Official Journal of the International Society on Toxinology·Jamie SeymourMark Little

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