Cardiotoxicity of β-mimetic catecholamines during ontogenetic development - possible risks of antenatal therapy

Canadian Journal of Physiology and Pharmacology
B OstádalF Kolár

Abstract

Catecholamines are involved in the regulation of a wide variety of vital functions. The β-adrenergic receptor (β-AR) - adenylyl cyclase system has been identified early in embryogenesis before the heart has received adrenergic innervation. The structure of β-receptors in the immature myocardium is similar to that in adults; there are, however, significant quantitative developmental changes in the inotropic and chronotropic responsiveness. Information on the toxic effect of the β-AR agonists in the immature heart is surprisingly scarce, even though these agents are used in clinical practice both during pregnancy and in early postnatal development. Large doses of β-AR agonists induce malformations of the cardiovascular system; the type of change depends upon the time at which the β-AR agonist was administered during embryogenesis. During postnatal ontogeny, the cardiotoxicity of β-AR agonists increased from birth to adulthood. It seems likely that despite interspecies differences, developmental changes in the cardiac sensitivity to β-AR agonists may exist in all mammals, depending on the degree of maturation of the system involved in β-adrenergic signaling. All the existing data draw attention to the possible harmful consequences...Continue Reading

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Related Concepts

MRNA Maturation
Catecholamine [EPC]
Late Effect of Medical Intervention
Regulation of Biological Process
Muscle Innervation, Function
Cardiovascular System
Antenatal Screening Procedures
Catecholamines Measurement
Chronotropism, Cardiac
Myocardium

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