Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study

Cancer Communications
Jianjun PengGong Chen

Abstract

5-Fluorouracil (5-FU) and capecitabine-associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date. In the present study, we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU- and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China. Among the 527 patients who completed the study, 196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy. Adverse events were reported during the treatment and up to 28 days of follow-up. Outcome measures included ECG, myocardial enzymes, cardiac troponin, brain natriuretic peptide and echocardiography. Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents. In total, 161 of 527 patients (30.6%) experienced cardiotoxicity. The incidence rate of cardiotoxicity was 33.8% (112/331) in the capecitabine group, whi...Continue Reading

References

Aug 1, 1990·Journal of Chemotherapy·B JeremicL Mijatovic
Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S RezkallaZ G Turi
Sep 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J EskilssonC Mercke
Nov 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CunninghamG Perez-Manga
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Meta-analysis Group In CancerE Levy
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G CocconiS M Hietschold
Apr 13, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J ClarkeY E Davidson
May 9, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemB Osterwalder
Jan 19, 2006·Cancer Chemotherapy and Pharmacology·Søren Astrup Jensen, Jens Benn Sørensen
Jul 20, 2007·Journal of Cancer Research and Clinical Oncology·Christos KosmasNicolas Tsavaris
Mar 25, 2009·Expert Opinion on Drug Safety·M Wasif SaifAnuj R Shah
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Cristina GravalosHernán Cortés-Funes
Sep 27, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollA Cervantes
Oct 9, 2012·Cardiology Journal·Michael F SorrentinoAlexander G Truesdell
Apr 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claire KellyMark Saunders
Dec 5, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D RansomT J Price

❮ Previous
Next ❯

Citations

May 22, 2020·The Oncologist·Chiara LestuzziMassimiliano Berretta
Feb 5, 2021·Current Cardiology Reports·Luis Alberto MoreAarti Asnani

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.