Cardiotoxicity of amitriptyline and doxepin

Clinical Pharmacology and Therapeutics
J M Tobis, W S Aronow

Abstract

The cardiotoxicity of the tricyclic antidepressants amitriptyline and doxepin were compared in an animal with acute overdose. The mean repetitive extrasystole threshold (RET) decreased 71.5% with amitriptyline and 27.5% with doxepin (mean blood levels 933 ng/ml and 1889 ng/ml). Physostigmine reversed these effects. Sodium bicarbonate had a variable effect on the lowered RET. The toxic arrhythmogenic effects of the tricyclic antidepressants can be measured by RET and are partly autonomic tone manipulation. In the same blood level range, doxepin is less toxic than amitriptyline.

Citations

Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader
Nov 1, 1982·Pacing and Clinical Electrophysiology : PACE·B StrasbergK Rosen
May 1, 1985·Journal of Clinical Pharmacology·E F Coccaro, L J Siever
Jan 1, 1982·Annals of the New York Academy of Sciences·M J Kreek, N Hartman
Jun 6, 2009·Expert Opinion on Pharmacotherapy·Harold W Goforth
Dec 1, 1984·Acta Anaesthesiologica Scandinavica·J StrømM Bredgaard Sørensen
Nov 27, 2015·Expert Opinion on Therapeutic Patents·Yifeng JinWon-Jea Cho
Feb 1, 1997·Journal of Clinical Psychopharmacology·B BakerM J Irvine
Aug 26, 1998·The Australian and New Zealand Journal of Psychiatry·E E Beerworth, J W Tiller
Sep 1, 1984·Drug Intelligence & Clinical Pharmacy·R A CurtisM Schaffer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Clinical Pharmacology and Therapeutics
J M Tobis, W S Aronow
Acta Psychiatrica Scandinavica. Supplementum
N Retterstøl
European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
M W DiltoerL P Huyghens
© 2021 Meta ULC. All rights reserved