Cardiotoxicity of Radiation Therapy: Mechanisms, Management, and Mitigation.

Current Treatment Options in Oncology
P EllA L Sverdlov

Abstract

Radiation therapy is a key component of modern-day cancer therapy and can reduce the rates of recurrence and death from cancer. However, it can increase risk of cardiovascular (CV) events, and our understanding of the timeline associated with that risk is shorter than previously thought. Risk mitigation strategies, such as different positioning techniques, and breath hold acquisitions as well as baseline cardiovascular risk stratification that can be undertaken at the time of radiotherapy planning should be implemented, particularly for patients receiving chest radiation therapy. Primary and secondary prevention of cardiovascular disease (CVD), as appropriate, should be used before, during, and after radiation treatment in order to minimize the risks. Opportunistic screening for subclinical coronary disease provides an attractive possibility for primary/secondary CVD prevention and thus mitigation of long-term CV risk. More data on long-term clinical usefulness of this strategy and development of appropriate management pathways would further strengthen the evidence for the implementation of such screening. Clear guidelines in initial cardiovascular screening and cardiac aftercare following radiotherapy need to be formulated in ...Continue Reading

References

Dec 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A FourquetJ R Vilcoq
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J CuzickH Host
Aug 22, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D LandauG Ross
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Stine S KorremanHåkan Nyström
Mar 8, 2007·Journal of the National Cancer Institute·Maartje J HooningFlora E van Leeuwen
May 8, 2007·Journal of the American College of Cardiology·Matthew J BudoffDaniel S Berman
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Apr 29, 2008·International Journal of Radiation Oncology, Biology, Physics·Mark W McDonaldPeter A S Johnstone
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Jun 13, 2009·JACC. Cardiovascular Imaging·Ammar SarwarKhurram Nasir
Apr 29, 2010·JAMA : the Journal of the American Medical Association·Tamar S PolonskyPhilip Greenland
Sep 25, 2010·Cancer Treatment Reviews·Cyrus ChargariYoulia M Kirova
Oct 16, 2010·Journal of the American College of Cardiology·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Oct 16, 2010·Journal of the American College of Cardiology·Suzette E Elias-SmaleJacqueline C M Witteman
Apr 12, 2012·Cancer Investigation·Philippe GiraudUNKNOWN Stic Study Centers
Apr 13, 2012·International Journal of Radiation Oncology, Biology, Physics·Stella C LymberisSilvia C Formenti
Aug 14, 2012·Journal of Medical Imaging and Radiation Oncology·Amy J HaydenKenneth Tiver
Dec 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Henrik D Nissen, Ane L Appelt
Jan 18, 2013·The New England Journal of Medicine·Anand K ParekhJanet S Wright
Mar 5, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Kelli A ReardonKrishni Wijesooriya
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall
Apr 3, 2013·Acta Oncologica·Zoltán VargaZsuzsanna Kahán
Sep 4, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patrizio LancellottiUNKNOWN American Society of Nuclear Cardiology, Society for Cardiovascular Magnetic Resonance, and Society of Cardiovascular Compute
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory T ArmstrongLillian R Meacham
Dec 18, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Youlia M KirovaAlain Fourquet
Feb 26, 2015·AJR. American Journal of Roentgenology·Farhood Saremi, Stephan Achenbach
Nov 5, 2015·International Journal of Radiation Oncology, Biology, Physics·David WiantBenjamin Sintay
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Nov 18, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederika A van NimwegenFlora E van Leeuwen
Jul 17, 2016·Journal of Radiation Research·Soile Tapio
Jan 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kyle WangLawrence B Marks
Jul 12, 2017·Heart, Lung & Circulation·Gary LiewChristian Hamilton-Craig
Jul 25, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Estelle BronsartYoulia M Kirova
Nov 11, 2017·Frontiers in Cardiovascular Medicine·Syed Wamique YusufSunil Krishnan

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