Cardiovascular actions of neurotrophins.

Physiological Reviews
Andrea Caporali, Costanza Emanueli

Abstract

Neurotrophins were christened in consideration of their actions on the nervous system and, for a long time, they were the exclusive interest of neuroscientists. However, more recently, this family of proteins has been shown to possess essential cardiovascular functions. During cardiovascular development, neurotrophins and their receptors are essential factors in the formation of the heart and critical regulator of vascular development. Postnatally, neurotrophins control the survival of endothelial cells, vascular smooth muscle cells, and cardiomyocytes and regulate angiogenesis and vasculogenesis, by autocrine and paracrine mechanisms. Recent studies suggest the capacity of neurotrophins, via their tropomyosin-kinase receptors, to promote therapeutic neovascularization in animal models of hindlimb ischemia. Conversely, the neurotrophin low-affinity p75(NTR) receptor induces apoptosis of endothelial cells and vascular smooth muscle cells and impairs angiogenesis. Finally, nerve growth factor looks particularly promising in treating microvascular complications of diabetes or reducing cardiomyocyte apoptosis in the infarcted heart. These seminal discoveries have fuelled basic and translational research and thus opened a new field ...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS P Squinto
Oct 1, 1992·Cardiovascular Research·B Rodrigues, J H McNeill
Jul 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P M SantosE W Rubel
Dec 10, 1991·Biochimica Et Biophysica Acta·M BarbacidR Klein
Jun 20, 1991·Journal of Molecular Biology·N Q McDonald, T L Blundell
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K R Jones, L F Reichardt
Nov 21, 1986·Cell·D JohnsonM Chao
Sep 1, 1987·Molecular and Cellular Biology·M J SelbyW J Rutter
Mar 15, 1994·International Journal of Cancer. Journal International Du Cancer·S MatteiM Herlyn
Jul 1, 1995·Trends in Neurosciences·M V Chao, B L Hempstead
Jun 1, 1995·The European Journal of Neuroscience·M P ArmaniniH S Phillips
May 1, 1995·The European Journal of Neuroscience·N OffenhäuserM Meyer
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E F PlowJ L Hoover-Plow
Sep 22, 1995·The Journal of Biological Chemistry·R T DobrowskyY A Hannun
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·D O Clary, L F Reichardt
Jul 16, 1993·Science·S RabizadehD E Bredesen
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M BenedettiM V Chao
Mar 25, 1993·The New England Journal of Medicine·A NakagawaraG M Brodeur

❮ Previous
Next ❯

Citations

Jan 30, 2010·In Vitro Cellular & Developmental Biology. Animal·Shimon LechtPeter I Lelkes
Jun 15, 1977·European Journal of Pharmacology·J D PickardA M Harper
May 1, 1976·The Journal of Surgical Research·L M GrahamW J Fry
Sep 1, 1977·Prostaglandins·M A Marrazzi, J H Daugherty
Jun 2, 2012·Zygote : the Biology of Gametes and Early Embryos·R N ChavesJ R Figueiredo
Apr 19, 2011·Cardiovascular Research·Lucas W MeuchelY S Prakash
Mar 16, 2011·Human Molecular Genetics·Nicole WagnerKay-Dietrich Wagner
Dec 6, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ahmed AlhusbanSusan C Fagan
Jul 26, 2011·Fiziologiia cheloveka·S A Kryzhnovskiĭ, M B Vititnova
Mar 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Bruce D CarterNazareno Paolocci
Mar 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Christina U LorentzBeth A Habecker
Apr 3, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Brunella CristofaroCostanza Emanueli
Oct 16, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrea CaporaliCostanza Emanueli
Apr 3, 2010·Circulation Research·Marco MeloniCostanza Emanueli
Dec 19, 2009·Stroke; a Journal of Cerebral Circulation·Anantha Vijay R SanthanamZvonimir S Katusic
May 24, 2012·Stroke; a Journal of Cerebral Circulation·Adviye ErgulSusan C Fagan
Jun 24, 2010·Molecular Cancer·Rodrigue RomonXuefen Le Bourhis
Jul 7, 2011·PloS One·Fatima SmihPhilippe Rouet
Jan 15, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Jennifer L StrandePhilip Lazarovici
Jun 9, 2010·Expert Review of Respiratory Medicine·Ys PrakashRichard J Martin
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ning FengNazareno Paolocci
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano GovoniEmilio Vanoli
Sep 2, 2009·Experimental Cell Research·Ilana MoscatelliLuisa Campagnolo
Dec 17, 2015·Omics : a Journal of Integrative Biology·Akanksha Gupta, Sonika Bhatnagar
Sep 10, 2014·Human Mutation·Petra WernerElizabeth Goldmuntz
Mar 27, 2010·Paediatric Anaesthesia·Morgan BlaylockBruno Bissonnette
Aug 14, 2015·IUBMB Life·Akriti S SahaySadhana R Joshi
Nov 25, 2014·Arthritis Research & Therapy·Kim LyMarie-Odile Jauberteau
Apr 24, 2015·Clinical and Experimental Pharmacology & Physiology·Maiko OharaHiroshi Inoue
Jun 27, 2015·Biochimica Et Biophysica Acta·Michael A ThompsonY S Prakash
Dec 4, 2013·Biochemical and Biophysical Research Communications·Akira AsanomeNaoyuki Hasebe
Mar 6, 2012·Microvascular Research·Koji IshitsukaTakanari Kitazono
Nov 3, 2012·European Journal of Pharmacology·Awahan RahmanKarl Swärd
Aug 1, 2015·American Journal of Respiratory and Critical Care Medicine·Vinicio A de Jesus Perez

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