PMID: 8945972Nov 1, 1996Paper

Cardiovascular actions of trout urotensin II in the conscious trout, Oncorhynchus mykiss

The American Journal of Physiology
Jean-Claude Le MévelJ M Conlon

Abstract

The central and peripheral cardiovascular effects of synthetic trout urotensin II (UII) were investigated in the conscious rainbow trout. Intracerebroventricular injection of 50 pmol UII produced a slight (3%) but significant (P < 0.05) increase in heart rate but had no effect on mean arterial blood pressure. Injection of 500 pmol UII icv produced a significant (P < 0.05) rise (8%) in blood pressure with no change in heart rate. In contrast to the weak pressor effect of centrally administered UII, intra-arterial injection of UII produced a dose-dependent increase in arterial blood pressure and decrease in heart rate with significant (P < 0.05) effects on both parameters observed at a dose of 25 pmol. Higher doses of the peptide produced a sustained decrease in cardiac output that accompanied the bradycardia and rise in arterial blood pressure. The UII-induced bradycardia, but not the increase in pressure, was abolished by pretreatment with phentolamine. Trout UII produced a sustained and dose-dependent contraction of isolated vascular rings prepared from trout efferent branchial [-log 50% of the concentration producing maximal contraction (pD2) = 8.30] and celiacomesenteric (pD2 = 8.22) arteries but was without effects on vascu...Continue Reading

Citations

Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T M HoaglandK R Olson
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigenori NobataYoshio Takei
Jul 13, 2002·The Journal of Experimental Zoology·Kenneth R Olson
Dec 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigenori NobataYoshio Takei
Oct 10, 2015·Journal of Materials Science. Materials in Medicine·Manoochehr RasekhDarek Gorecki
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N MimassiJ C Le Mével

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