Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.

American Journal of Physiology. Heart and Circulatory Physiology
Amina KunovacJohn M Hollander


Ambient air, occupational settings, and the use and distribution of consumer products all serve as conduits for toxicant exposure through inhalation. While the pulmonary system remains a primary target following inhalation exposure, cardiovascular implications are exceptionally culpable for increased morbidity and mortality. The epidemiological evidence for cardiovascular dysfunction resulting from acute or chronic inhalation exposure to particulate matter has been well documented, but the mechanisms driving the resulting disturbances remain elusive. In the current review, we aim to summarize the cellular and molecular mechanisms that are directly linked to cardiovascular health following exposure to a variety of inhaled toxicants. The purpose of this review is to provide a comprehensive overview of the biochemical changes in the cardiovascular system following particle inhalation exposure and to highlight potential biomarkers that exist across multiple exposure paradigms. We attempt to integrate these molecular signatures in an effort to provide direction for future investigations. This review also characterizes how molecular responses are modified in at-risk populations, specifically the impact of environmental exposure durin...Continue Reading


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Aug 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Claudio Nardiello, Rory E Morty

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Methods Mentioned

histone acetylation
nuclear translocation
nucleotide exchange

Software Mentioned

ingenuity pathway analysis ( IPA

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