Cardiovascular Adaptive Homeostasis in Exercise

Frontiers in Physiology
Kelvin J A Davies

Abstract

Adaptive Homeostasis has been defined as, "The transient expansion or contraction of the homeostatic range in response to exposure to sub-toxic, non-damaging, signaling molecules or events, or the removal or cessation of such molecules or events." (Davies, 2016). I propose that one of the most significant examples of adaptive homeostasis may be the adaptation of the cardiovascular system to exercise training. In particular, endurance type training involves the generation of increased levels of free radicals such as ubisemiquinone, superoxide, nitric oxide, and other (non-radical) reactive oxygen species such as hydrogen peroxide (H2O2), in a repetitive manner, typically several times per week. As long as the training intensity and duration are sub-maximal and not exhaustive these reactive species do not cause damage, but rather activate signal transduction pathways to induce mitochondrial biogenesis-the foundation of increased exercise endurance. Particularly important are the NFκB and Nrf2 signal transduction pathways which respond to reactive oxygen and nitrogen species generated during exercise. As with other examples of adaptive homeostasis the effects are transient, lasting only as long as the training is maintained. Unfor...Continue Reading

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Citations

Apr 2, 2020·Journal of Translational Medicine·Roberto RoklicerPatrik Drid
Aug 8, 2019·International Journal of Molecular Sciences·Simona DamianoMariarosaria Santillo
Aug 10, 2020·Free Radical Biology & Medicine·Maria Paola ParonettoDaniela Caporossi
Mar 24, 2020·Redox Biology·John TowerKelvin J A Davies

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Methods Mentioned

BETA
electron spin resonance

Related Concepts

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Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

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