Cardiovascular Adverse Effects of Phenylephrine Eyedrops: A Systematic Review and Meta-analysis

JAMA Ophthalmology
Bethany StavertRobert P Finger

Abstract

Topical phenylephrine hydrochloride is routinely administered with few safety precautions, but evidence regarding its systemic safety to date is controversial. As even short-term variations in 24-hour blood pressure (BP) and heart rate (HR) can adversely affect cardiovascular health, better evidence on phenylephrine's effects on HR and BP is required. To perform a meta-analysis of available evidence regarding cardiovascular adverse effects of topical phenylephrine. PubMed, MEDLINE, and the Cochrane Database of Systematic Reviews and Clinical Trials were searched for relevant literature from January 1, 1970, to January 1, 2014, using a combination of the following search terms: topical, ocular, ophthalmic, phenylephrine, tropicamide, cardiovascular effect, side effect, blood pressure, heart rate, mydriatic, and eye drops. A total of 70 articles related to the topic were identified and all full texts were retrieved. Randomized clinical trials reporting change in BP and HR for adults were included in this review. All studies reporting results for neonates or infants, not reporting standard deviations, or not specifying the time of measurement or the concentration of phenylephrine used were excluded. Data from randomized clinical t...Continue Reading

Citations

Jan 5, 2018·The Open Ophthalmology Journal·Anu Vaajanen, Heikki Vapaatalo
Jan 10, 2018·Medicinal Research Reviews·Přemysl MladěnkaUNKNOWN TOX-OER and CARDIOTOX Hradec Králové Researchers and Collaborators
Jul 5, 2016·Journal of Cataract and Refractive Surgery·William G Myers
Sep 17, 2019·Clinical & Experimental Ophthalmology·Luzia MüllerAnthony P Wells
Apr 2, 2019·Current Eye Research·Harry W RobertsDavid P S O'Brart
Jan 1, 2016·Vestnik oftalmologii·Y O GrushaI V Blinova
Mar 10, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Junsang ChoSusan M Culican
May 23, 2021·Headache·William ColemanChantal J Boisvert
Oct 8, 2021·Investigative Ophthalmology & Visual Science·Arash KazemiArthur J Sit
Jun 9, 2020·Ocular Oncology and Pathology·Vittoria Arslan-CarlonDavid H Abramson

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