Cardiovascular alterations do exist in children with stage-2 chronic kidney disease

Clinical and Experimental Nephrology
Mehmet TaşdemirLale Sever

Abstract

Cardiovascular disease (CVD) is an important complication of chronic kidney disease (CKD) in children. However, it is not well known when and how cardiovascular alterations start. This cross-sectional, controlled study consisted of 25 patients and 28 healthy controls. 24-h ambulatory blood pressure monitoring, aortic pulse wave velocity (aPWV), carotid intima-media thickness (cIMT) and carotid distensibility (distensibility coefficient and β stiffness index), and echocardiography were assessed to evaluate CVD. Routine biochemical parameters, fibroblast growth factor-23 (FGF23) and high sensitive C- reactive protein were measured to determine cardiovascular risk factors. Hypertension was found in 12 patients (48 %). Patients had higher FGF23 levels and aPWV-standard deviation score (SDS) as compared to the controls (p = 0.003 and p = 0.002, respectively). Aortic PWV-SDS was predicted by increased daytime systolic blood pressure load (β = 0.512, p = 0.009, R 2 = 0.262). Neither cIMT nor distensibility differed between the groups; however, older age and high level of FGF23 were independent predictors of β stiffness index in patients (β = 0.507, p = 0.005, R 2 = 0.461 and β = 0.502, p = 0.005, R 2 = 0.461, respectively). As compare...Continue Reading

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Citations

Sep 8, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Karolis AzukaitisRukshana Shroff
Aug 10, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amy C Wilson, Joseph T Flynn
Nov 13, 2021·Indian Journal of Pediatrics·Gaurav SinghRabindra N Mishra

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