PMID: 7518305May 1, 1994Paper

Cardiovascular and behavioural effects of centrally administered neuropeptide K in the rat: receptor characterization

British Journal of Pharmacology
A PratR Couture

Abstract

1. The cardiovascular and behavioural responses to intracerebroventricularly (i.c.v.) administered neuropeptide K (NPK) were studied in conscious rats. The central effects of NPK were characterized by pretreatment (i.c.v.) with selective antagonists for the NK1 ((+/-)-CP 96345 and RP 67580), NK2 (SR 48968) and NK3 (R 487) receptors. 2. NPK (10-65 pmol) induced tachycardia and dose-dependent increases of mean arterial blood pressure. The cardiovascular responses reached a maximum within 3 min post-injection and lasted for more than 1 h. Concurrently, NPK produced dose-dependent increases of face washing, head scratching, grooming, walking and wet dog shakes. 3. A desensitization of most of the behavioural responses (except head scratching) but not of the cardiovascular response was shown when two consecutive injections of 25 pmol NPK were given 24 h apart. 4. Both the cardiovascular and behavioural responses (except the head scratching) to 25 pmol NPK were blocked by pre-administration (i.c.v.) of 6.5 nmol (+/-)-CP 96345 or RP 67580 given 5 min earlier. No inhibition of NPK responses was observed when 6.5 nmol SR 48968 or R 487 were used in a similar study. Additionally, NPK effects were significantly reduced 24 h after the prio...Continue Reading

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Citations

Jan 20, 2004·Life Sciences·Jocelyn N PennefatherCarlo Alberto Maggi
Jan 9, 1999·European Journal of Pharmacology·J Goldhill, I Angel
May 12, 2004·Peptides·Jean-Claude BeaujouanJacques Glowinski
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·R CoutureA Prat
Mar 10, 2015·Endocrinology·Chitrang TrivediDiego Perez-Tilve
Aug 11, 2000·Journal of Neurochemistry·J C BeaujouanJ Glowinski
Aug 14, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jinxin WangMark A Cline

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