Cardiovascular and behavioural responses to conditioned fear and restraint are not affected by retrograde lesions of A5 and C1 bulbospinal neurons

Neuroscience
D M L Vianna, P Carrive

Abstract

The aim of this study was to test a possible role of A5 neurons in the expression of the pressor and tachycardic responses to conditioned fear and restraint, two forms of psychological stress. Previous Fos studies have shown that the C1 adrenergic neurons and spinally projecting neurons in the vasopressor region of the rostral ventrolateral medulla are not activated by these two stressors, suggesting that these cardiovascular changes may be mediated by other premotor sympathetic (presympathetic) cell groups. The same studies also revealed that the A5 noradrenergic group was one of the main presympathetic cell groups to be activated in response to these two stressors. Thus, we hypothesized that the A5 group could mediate these cardiovascular responses. Conditioned fear and restraint were tested in rats implanted with radiotelemetric probes before and after retrograde lesion with the selective toxin anti-dopamine-beta-hydroxylase-saporin bilaterally injected in the spinal cord at T2-T3. Six animals were selected that had the most extensive loss of spinally projecting catecholaminergic neurons: A5 (81%-95%) and rostral C1 (59%-86%, which would include most C1 bulbospinal neurons). However, despite this major loss of noradrenergic ...Continue Reading

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Jun 4, 2005·The European Journal of Neuroscience·Daniel M L Vianna, Pascal Carrive
Dec 23, 2006·Clinical and Experimental Pharmacology & Physiology·Pascal Carrive
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Jul 21, 2009·The International Journal of Social Psychiatry·Ioannis Paxinos, Anastasia Kalantzi-Azizi

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Citations

Nov 28, 2013·Journal of Hypertension·Kristy L JacksonGeoffrey A Head
Jan 15, 2014·Autonomic Neuroscience : Basic & Clinical·Ruei-Jen ChiouChen-Tung Yen
Dec 5, 2014·BMC Neuroscience·Adrian M StankiewiczPaweł Lisowski
Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter G R BurkeAnn K Goodchild

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