PMID: 3768735Aug 1, 1986Paper

Cardiovascular and drinking responses elicited by central administration of angiotensin II: differential effects of GABA injected into the ventral tegmental area and spiperone injected into the nucleus accumbens

Brain Research Bulletin
D L Jones

Abstract

The ventral tegmental area and its dopamine projections to the nucleus accumbens have been shown to be involved in goal-directed behavior. This study investigated the contribution of GABAergic input to the ventral tegmental area and dopaminergic input to the nucleus accumbens to the drinking and cardiovascular responses elicited by central administration of angiotensin II. Injections of 25 ng of angiotensin II into a lateral cerebral ventricle of the conscious rat elicited water intakes averaging 8 ml in 15 min with latencies usually less than 3 min. Pretreatment of the nucleus accumbens with spiperone, a dopamine antagonist, or the ventral tegmental area with gamma-amino butyric acid (GABA) produced dose-dependent reductions in water intake and number of laps taken while increasing the latency to drink. Injections of spiperone into the nucleus accumbens in anesthetized animals failed to alter the cardiovascular response elicited following the central administration of angiotensin II. However, administration of GABA into the ventral tegmental of urethane anaesthetized animals attenuated the pressor response normally elicited by central administration of angiotensin II. These findings suggest that GABA input to the ventral tegme...Continue Reading

References

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Citations

Jan 1, 1993·Brain Research Bulletin·D J Calcagnetti, M D Schechter
Mar 24, 2006·Cell and Tissue Research·O von Bohlen und Halbach, D Albrecht

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