Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: Results from the German Competence Network, CAPNETZ

American Journal of Respiratory and Critical Care Medicine
Stefan KrügerGerman Competence Network for the Study of Community Acquired Pneumonia (CAPNETZ) Study Group

Abstract

Several new biomarkers are related to mortality in community-acquired pneumonia (CAP). Aim of this study was to compare new biomarkers for the prediction of short- and long-term all-cause mortality in CAP. We enrolled 728 patients (59.0 ± 18.2 yr) with CAP. Midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide (MR-proANP), proarginin-vasopressin (copeptin), proendothelin-1 (CT-proET-1), procalcitonin (PCT), C-reactive protein, white blood cell (WBC) count, and clinical confusion, respiratory rate, blood pressure, and age over 65 years (CRB-65) score were determined on admission. Patients were followed up for 180 days. In patients who died of any cause within 28 and 180 days (2.5 and 5.1%, respectively), MR-proADM, MR-proANP, copeptin, CT-proET-1 and PCT as well as CRB-65 were significantly higher compared with survivors. MR-proADM had the best performance for 28 days (HR 3.67) and 180 days (HR 2.84) survival. The C index of MR-proADM for 28-day survival (0.85) was superior to MR-proANP (0.81), copeptin (0.78), CT-proET-1 (0.79), and CRB-65 (0.72) for the prediction of mortality. For prediction of mortality at 180 days, the C index of MR-proADM (0.78) was higher than that for MR-proANP (0.74), cope...Continue Reading

References

Jan 23, 1997·The New England Journal of Medicine·M J FineW N Kapoor
Apr 26, 2000·The European Respiratory Journal·J AlmirallX Balanzó
Mar 27, 2001·Seikagaku. The Journal of Japanese Biochemical Society·K Takahashi
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric M MortensenMichael J Fine
Dec 25, 2003·American Journal of Respiratory and Critical Care Medicine·Grant W WatererRichard G Wunderink
Jan 8, 2004·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Aug 5, 2004·Infection·T WelteR Marre
Feb 8, 2005·Critical Care : the Official Journal of the Critical Care Forum·Nils G MorgenthalerBeat Müller
Jul 26, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Todd C CarpenterKurt R Stenmark
Aug 16, 2005·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Nov 5, 2005·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Dec 17, 2005·Critical Care : the Official Journal of the Critical Care Forum·Mirjam Christ-CrainBeat Müller
Jan 3, 2006·The European Respiratory Journal·S EwigM Woodhead
Jan 3, 2006·The European Respiratory Journal·A CapelasteguiA Bilbao
Jan 21, 2006·Critical Care Medicine·Stefan JochbergerMartin W Dünser
Apr 11, 2006·American Journal of Respiratory and Critical Care Medicine·Mirjam Christ-CrainBeat Müller
Jun 23, 2006·Journal of Internal Medicine·T T BauerUNKNOWN CAPNETZ Study Group
Jun 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Mirjam Christ-CrainBeat Müller
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Stefan JochbergerMartin W Dünser
Nov 23, 2006·Journal of Internal Medicine·B MüllerM Christ-Crain
Sep 11, 2007·The Journal of Infection·Cristina PratVicente Ausina
Oct 26, 2007·The European Respiratory Journal·S KrügerUNKNOWN CAPNETZ Study Group
Mar 29, 2008·American Journal of Respiratory and Critical Care Medicine·Sachin YendeUNKNOWN GenIMS Investigators

❮ Previous
Next ❯

Citations

May 3, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T Welte
Aug 27, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A LacomaJ Domínguez
Sep 27, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P P EspañaUNKNOWN Population Study of Pneumonia (PSoP) Group
Feb 5, 2013·Current Infectious Disease Reports·Stefano AlibertiFrancesco Blasi
Apr 9, 2013·Current Opinion in Critical Care·Anthony S McLean
Sep 3, 2013·Current Opinion in Critical Care·Matthieu Legrand, Etienne Gayat
Mar 17, 2012·Current Opinion in Infectious Diseases·Christoph LichtensternMarkus A Weigand
Feb 22, 2013·Current Opinion in Infectious Diseases·Marcos I RestrepoAntonio Anzueto
Sep 29, 2011·Antimicrobial Agents and Chemotherapy·Hui LiCan-Mao Xie
Jun 23, 2011·American Journal of Respiratory and Critical Care Medicine·Andrea CorsonelloRaffaele Antonelli Incalzi
Jul 19, 2011·American Journal of Respiratory and Critical Care Medicine·Richard G Wunderink, Grant W Waterer
Jan 26, 2013·The European Respiratory Journal·Werner C AlbrichBeat Müller
Jun 19, 2013·BMC Infectious Diseases·Christian G CornelissenStefan Krüger
Dec 9, 2010·Critical Care : the Official Journal of the Critical Care Forum·Michel Wolff, Lila Bouadma
Oct 26, 2012·Journal of Geriatric Cardiology : JGC·Rajiv ChoudharyAlan S Maisel
Feb 22, 2014·Médecine et maladies infectieuses·P Hausfater
Jun 3, 2014·BMC Medicine·Kasper IversenLars Køber
May 31, 2014·Revista española de geriatría y gerontología·Juan González Del CastilloJosé Barberán
Oct 16, 2015·American Journal of Respiratory and Critical Care Medicine·Clarissa ValimQuique Bassat
Nov 5, 2013·Enfermedades infecciosas y microbiología clínica·Agustín Julián-JiménezRafael Cuena-Boy
Oct 15, 2013·Medicina clínica·Agustín Julián-JiménezPablo Gallardo Schall
Apr 7, 2012·Revista Clínica Espanõla·A Julián-JiménezF J Candel González
Aug 12, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Stefan KrügerUNKNOWN CAPNETZ study group
Mar 10, 2016·BMC Pulmonary Medicine·Masato TashiroKoichi Izumikawa
Mar 18, 2016·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Norbert SuttorpUNKNOWN CAPNETZ-Studiengruppe
May 2, 2014·Life Sciences·Brandi D FreemanMahalia S Desruisseaux
Dec 3, 2016·Expert Review of Clinical Pharmacology·Faheem KhanIgnacio Martin-Loeches
Dec 12, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yosuke SuzukiMasaharu Takeyama

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