PMID: 5914256Sep 1, 1966

Cardiovascular and metabolic responses to noradrenaline in man, before and after acclimatization to cold in Antarctica

The Journal of Physiology
G M Budd, N Warhaft

Abstract

1. Four men of European descent were infused with noradrenaline at rates of 0.038, 0.075, 0.150 and 0.300 mug/kg.min in Australia, and again after 29 weeks' residence at Mawson, Antarctica. A concurrent study of their responses to whole-body cooling showed that they acclimatized to cold in Antarctica.2. Blood pressure rose and heart rate fell in proportion to the dose of noradrenaline infused. The response was much less after than before acclimatization in three of the four subjects. Subjective effects of the drug decreased in proportion to the decrease in the pressor effect.3. Finger temperature fell in proportion to the dose infused, in three subjects. The response was unchanged or increased after acclimatization.4. Oxygen consumption was initially unaffected by noradrenaline, but after acclimatization it apparently increased in proportion to the dose infused. The increase in pulmonary ventilation during infusion was slightly greater after acclimatization.

Citations

Dec 1, 1993·International Journal of Biometeorology·M Naidu, U Sachdeva
Sep 1, 1978·International Journal of Biometeorology·A S Bodey
Jul 6, 2000·Journal of Thermal Biology·M SimeckováP Srámek
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·G M BuddA T Solaga
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·G M BuddA T Solaga
Mar 15, 1997·Annals of the New York Academy of Sciences·L JanskýM Simecková
Oct 7, 2011·Journal of Diabetes Investigation·Chong Yew TanAntonio Vidal-Puig
Apr 1, 1980·Acta Anaesthesiologica Scandinavica·K Jessen
Oct 5, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Denis P Blondin, André C Carpentier
Jun 1, 1970·International Journal of Biometeorology·S ItoA Kuroshima
Dec 1, 1969·International Journal of Biometeorology·L Janský
Feb 1, 1973·Biological Reviews of the Cambridge Philosophical Society·L Janský

Related Concepts

Acclimatization
Diastolic Blood Pressure
Heart
Norepinephrine, (+, -)-Isomer
Oxygen Consumption
Pulmonary Circulation

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