PMID: 2483441Jan 1, 1989Paper

Cardiovascular and renal action of dopaminergic prodrugs.

Journal of Cardiovascular Pharmacology
C CasagrandeC Semeraro

Abstract

The possibility of exploiting the cardiovascular and renal action of dopamine for therapeutic purposes is enhanced by its conversion into orally active prodrugs. Following an outline of the medicinal chemistry bases of the development of these prodrugs, laboratory and clinical pharmacology of ibopamine, levodopa, gludopa, and TA-870 are reviewed, pointing out the interesting indications of various preliminary studies in heart failure, essential hypertension, and renal failure on the one hand, and the extensive therapeutic experience with ibopamine as an "inodilator" in the chronic treatment of congestive heart failure on the other hand. New experimental results are also reported for ibopamine and for the novel prodrug Sim 2055, i.e., epinine-4-O-phosphate. The latter is shown to act as a selective renal vasodilator on oral administration in dogs and it is therefore proposed for clinical investigation in renal failure and in essential hypertension.

Citations

Jan 1, 1990·Journal of Autonomic Pharmacology·C CasagrandeA La Regina
Mar 1, 1995·Clinical Cardiology·M Metra, L Dei Cas
May 6, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·J W McLarenR F Brubaker
Sep 4, 2013·Chemical Biology & Drug Design·Rafik Karaman

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